Li Jiayao, Peng Yi, Zhan Di, Zhang Ying, Yu Shanshan
Hematology Department Nursing Platform, First Hospital of Jilin University, Xinmin Street, Changchun City, Jilin Province, 130021, China.
BMC Sports Sci Med Rehabil. 2025 Jun 9;17(1):148. doi: 10.1186/s13102-025-01193-4.
Patients with multiple myeloma (MM) frequently experience impaired motor function and reduced quality of life. While exercise interventions play a vital role, no standardized guidelines tailored specifically to MM patients currently exist. This article reviews the scope of exercise interventions for patients with MM and further analyzes the current situation, providing references for early rehabilitation.
This article aims to systematically analyze the application of exercise interventions in the rehabilitation of patients with MM, clarify the specific content, outcome indicators, and effects of exercise interventions, and provide relevant references for medical staff.
Using a scoping review methodology, we systematically conducted computerized searches across both Chinese (e.g., CNKI, Wanfang, Chinese Biomedical Literature Database) and international databases (e.g., Cochrane Library, PubMed, Embase) in accordance with the PRISMA-ScR checklist. The search timeframe encompassed records from database inception through 1 October 2024. Relevant literature meeting inclusion criteria underwent systematic summarization and critical analysis.
A total of 17 studies were included, comprising 10 randomized controlled trials (RCTs), 4 single-arm trials, 1 retrospective cohort study, and 2 quasi-experimental studies. The types of exercise included aerobic exercise, resistance training, and Nordic walking (with a frequency of 3 to 5 times per week for 30 to 60 min each session).
Although existing studies exhibit inconsistencies in exercise types, parameters, supervision protocols, and limited evidence quality, our scoping review of relevant research findings demonstrates that exercise interventions positively improved fatigue levels, functional capacity, quality of life, and psychological well-being in patients with multiple myeloma (MM). This conclusion holds clinical relevance, as it not only addresses patients' concerns regarding exercise safety but also provides evidence-based guidance for healthcare professionals in developing personalized exercise plans tailored to patients at different treatment stages. Future research should prioritize establishing standardized, individualized exercise protocols based on patient profiles, particularly for those with bone metastases.
Open Science Framework ( https://doi.org/10.17605/OSF.IO/UDWM4 ).
多发性骨髓瘤（MM）患者经常出现运动功能受损和生活质量下降的情况。虽然运动干预起着至关重要的作用，但目前尚无专门针对MM患者的标准化指南。本文回顾了MM患者运动干预的范围，并进一步分析现状，为早期康复提供参考。
本文旨在系统分析运动干预在MM患者康复中的应用，阐明运动干预的具体内容、结局指标和效果，为医务人员提供相关参考。
采用范围综述方法，我们按照PRISMA-ScR清单，在中国（如中国知网、万方、中国生物医学文献数据库）和国际数据库（如Cochrane图书馆、PubMed、Embase）中系统地进行计算机检索。检索时间范围涵盖从数据库建立到2024年10月1日的记录。符合纳入标准的相关文献进行了系统总结和批判性分析。
共纳入17项研究，包括10项随机对照试验（RCT）、4项单臂试验、1项回顾性队列研究和2项准实验研究。运动类型包括有氧运动、抗阻训练和北欧健走（每周3至5次，每次30至60分钟）。
尽管现有研究在运动类型、参数、监督方案方面存在不一致，且证据质量有限，但我们对相关研究结果的范围综述表明，运动干预能积极改善多发性骨髓瘤（MM）患者的疲劳水平、功能能力、生活质量和心理健康。这一结论具有临床意义，因为它不仅解决了患者对运动安全性的担忧，还为医疗保健专业人员制定针对不同治疗阶段患者的个性化运动计划提供了循证指导。未来的研究应优先根据患者情况建立标准化、个性化的运动方案，特别是对于有骨转移的患者。
