Huang Huan, Zhou Yaxin, Li Jiehang, Zhang Zhijin, Han RongJia, Zuo Jingru, Bai Yubin, Zhang Jiyu
Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou, China.
Ministry of Agriculture, Key Laboratory of Veterinary Pharmaceutical Development, Lanzhou, China.
Drug Deliv. 2025 Dec;32(1):2514140. doi: 10.1080/10717544.2025.2514140. Epub 2025 Jun 10.
Bacterial diseases are a significant challenge to human and animal health. The current treatment methods still have obvious shortcomings, such as poor targeting, low bioavailability, high side effects and drug resistance. Chitosan, with its outstanding biocompatibility, biodegradability, adhesiveness, antimicrobial properties, and ability to minimize drug side effects while improving bioavailability and therapeutic outcomes, serves as an ideal material for drug delivery systems, presenting a promising strategy for treating bacterial diseases. In this review, we briefly summarize the preparation methods of chitosan-based drug delivery systems and their application in the treatment of bacterial infections. The advantages of preparation of different types of chitosan-based drug delivery systems are discussed, supported by examples demonstrating their ability to improve drug antimicrobial activity, targeting, and bioavailability. Moreover, the current challenges, limitations, and future perspectives in this field were discussed, laying the groundwork for further development of chitosan-based drug delivery systems as high-performance and safe antimicrobial therapeutics.
细菌性疾病对人类和动物健康构成重大挑战。目前的治疗方法仍存在明显不足，如靶向性差、生物利用度低、副作用大以及耐药性等问题。壳聚糖具有出色的生物相容性、生物降解性、粘附性、抗菌性能，并且能够在提高生物利用度和治疗效果的同时将药物副作用降至最低，是药物递送系统的理想材料，为治疗细菌性疾病提供了一种有前景的策略。在本综述中，我们简要总结了基于壳聚糖的药物递送系统的制备方法及其在治疗细菌感染中的应用。讨论了不同类型基于壳聚糖的药物递送系统制备的优点，并举例说明它们提高药物抗菌活性、靶向性和生物利用度的能力。此外，还讨论了该领域当前面临的挑战、局限性和未来前景，为将基于壳聚糖的药物递送系统进一步开发为高性能和安全的抗菌治疗药物奠定基础。
