Rosas Herminia Diana, Morgan Xochitl C, Tao Yiran, Lai Florence, Mercaldo Nathaniel D
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Alzheimers Dement. 2025 Jun;21(6):e70330. doi: 10.1002/alz.70330.
Gut dysbiosis has been found to play a role in sporadic Alzheimer's disease (AD) but has not been explored in Down syndrome (DS), despite the strong relationship between DS and early AD. Here, we compared the gut microbiomes of 20 adults with DS, either cognitively stable or with mild cognitive impairment.
DNA from stool samples was profiled using 16S rRNA sequencing.
Cognitive status was associated with a significant difference in overall microbiome composition (p < 0.01) and with significant differences in the abundance of Bacteroidaceae, Enterobacteriaceae, and Christensenellaceae.
Just as in sporadic AD, AD in DS is associated with gut dysbiosis. Our work suggests that this is an important area for future investigation, one that may provide a novel and important target for therapeutic intervention.
Alterations in the gut microbiome are present in adults with Down syndrome (DS) with mild cognitive impairment (MCI). Increased taxa in DS-MCI that contribute to inflammation and disrupt blood-brain barrier. Suggests a possible role of gut dysbiosis in Alzheimer's disease in adults with DS.
肠道微生物群失调已被发现与散发性阿尔茨海默病（AD）有关，但尽管唐氏综合征（DS）与早期AD之间存在密切关系，却尚未在DS中进行研究。在此，我们比较了20名认知稳定或有轻度认知障碍的成年DS患者的肠道微生物群。
使用16S rRNA测序对粪便样本中的DNA进行分析。
认知状态与整体微生物群组成的显著差异（p < 0.01）以及拟杆菌科、肠杆菌科和克里斯滕森菌科丰度的显著差异有关。
与散发性AD一样，DS中的AD与肠道微生物群失调有关。我们的研究表明，这是未来研究的一个重要领域，可能为治疗干预提供一个新的重要靶点。
患有轻度认知障碍（MCI）的唐氏综合征（DS）成年患者存在肠道微生物群改变。DS-MCI中导致炎症和破坏血脑屏障的分类群增加。提示肠道微生物群失调在患有DS的成年人患阿尔茨海默病中可能起作用。
