Navalkar Krupa, Wheelock Alyse, Gregory Melissa, Clark Danielle, Kibuuka Hannah, Okello Stephen, Atukunda Sharon, Wailagala Abdullah, Waitt Peter, Kakooza Francis, Oduro George, Adams Nehkonti, Dietrich Maximilian, von der Forst Maik, Schultz Marcus J, Aggarwal Neil R, Greenberg Jared A, Yager Thomas D, Brandon Richard B
Immunexpress Inc., Seattle, WA 98109, USA.
Austere Environments Consortium for Enhanced Sepsis Outcomes (ACESO), Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
medRxiv. 2025 May 13:2025.05.09.25327025. doi: 10.1101/2025.05.09.25327025.
Early diagnosis and identification of causative pathogens using blood culture in patients suspected of Blood Stream Infection (BSI) and sepsis are critical for improving patient outcomes through early and more targeted treatment.
Post-hoc retrospective analysis of indiviudal patient data from three prospective clinical studies, conducted in North America, Europe and Africa, to investigate the association between SeptiCyte RAPID test results (SeptiScores) and blood culture results.
that a significant correlation exists between elevated SeptiScores and positive blood culture results, and between low SeptiScores and negative blood culture results.
As the SeptiScore increases, the relative probabilty of a septic patient being BC(+) as opposed to BC(-) also increases. A non-linear positive correlation is observed. Below SeptiScores of 10, the ratio of probabilities of BC(+) sepsis / BC(-) sepsis is <1 while above SeptiScores of 10 this ratio is >1. Thus, septic patients with SeptiScores >10 have a higher probability of being BC(+) compared to BC(-).
Elevated SeptiScores, obtained before blood culture results, are indicative of increased blood culture positivity. This may have clinical utility, particularly in resource limited settings, as an aid for improving the efficiency of blood culture practice, for instance by informing patient selection and interpretation of blood culture results.
对于疑似血流感染（BSI）和脓毒症的患者，通过血培养进行早期诊断并识别致病病原体，对于通过早期和更具针对性的治疗改善患者预后至关重要。
对在北美、欧洲和非洲进行的三项前瞻性临床研究中的个体患者数据进行事后回顾性分析，以研究SeptiCyte RAPID检测结果（SeptiScores）与血培养结果之间的关联。
SeptiScores升高与血培养阳性结果之间、低SeptiScores与血培养阴性结果之间存在显著相关性。
随着SeptiScore升高，脓毒症患者血培养阳性（BC(+)）而非血培养阴性（BC(-)）的相对概率也增加。观察到非线性正相关。在SeptiScores低于10时，BC(+)脓毒症/BC(-)脓毒症的概率比<1，而在SeptiScores高于10时，该比值>1。因此，与BC(-)相比，SeptiScores>10的脓毒症患者血培养阳性的概率更高。
在获得血培养结果之前获得的升高的SeptiScores表明血培养阳性率增加。这可能具有临床实用性，特别是在资源有限的环境中，有助于提高血培养实践的效率，例如通过指导患者选择和血培养结果的解读。
