Kondo Shinya, Itai Toshiyuki, Akamatsu Chika, Saitoh Shin, Iwata Akiko, Hamanoue Haruka, Hirahara Fumiki, Ishiwata Isamu, Shinoda Satoru, Miyagi Etsuko, Kurasawa Kentaro
Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
Japan Association of Obstetricians and Gynecologists, Shinjuku, Tokyo, Japan.
Congenit Anom (Kyoto). 2025 Jan-Dec;65(1):e70013. doi: 10.1111/cga.70013.
The Fukushima Daiichi Nuclear Disaster (FDND) occurred in 2011, which occurred after the Great East Japan Earthquake. However, how the incidence of radiation-induced malformations in Fukushima has been affected by FDND remains to be elucidated. To address this, we analyzed birth data from Fukushima and other areas in Japan from the International Clearinghouse for Birth Defects Surveillance and Research Japan Center, including information on birth defects between January 2010 and December 2022. Among the registered birth defects, microcephaly, microphthalmia, and neural tube defects were classified as radiation-induced malformations. Our study included 90 433 births in Fukushima, accounting for 52.6% of all births. Among these, birth defects were observed in 1376 (1.52%) births, of which 28 (0.031%) were diagnosed with radiation-induced malformations. With regard to other areas in Japan, 1 323 391 births, which accounted for 10.9% of all births, were registered; births with birth defects and radiation-induced malformations were observed in 37 490 (3.67%) and 889 (0.067%), respectively. Because sampling bias was suspected, we compared the rates of radiation-induced malformations in Fukushima and other areas in Japan by adjusting the incidence in Fukushima with the incidences of ventricular septal defects in both areas. However, there was no statistically significant difference between them. Our results, which covered the largest number of births in Fukushima, did not find a significant increase in the incidence of radiation-induced malformations in Fukushima since FDND.
福岛第一核电站核灾难（FDND）发生于2011年，是在东日本大地震之后发生的。然而，福岛辐射诱发畸形的发生率如何受到FDND的影响仍有待阐明。为解决这一问题，我们分析了来自日本国际出生缺陷监测与研究信息中心的福岛及日本其他地区的出生数据，包括2010年1月至2022年12月期间的出生缺陷信息。在登记的出生缺陷中，小头畸形、小眼畸形和神经管缺陷被归类为辐射诱发畸形。我们的研究包括福岛的90433例出生，占所有出生的52.6%。其中，1376例（1.52%）出生观察到出生缺陷，其中28例（0.031%）被诊断为辐射诱发畸形。关于日本其他地区，登记了1323391例出生，占所有出生的10.9%；分别在37490例（3.67%）和889例（0.067%）出生中观察到有出生缺陷和辐射诱发畸形。由于怀疑存在抽样偏差，我们通过用两个地区室间隔缺损的发生率调整福岛的发生率，比较了福岛和日本其他地区辐射诱发畸形的发生率。然而，它们之间没有统计学上的显著差异。我们的研究结果涵盖了福岛最多的出生人数，未发现自FDND以来福岛辐射诱发畸形的发生率有显著增加。
