Ma Ronald Cw, Chow Edith Wk, Ng Noel Yh, Sugiyama Takashi, Deng Yuzhi, Tam Wing Hung, Lau So Ling, Poon Liona C, Zhang Cuilin, Sriram Usha
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Laboratory for Molecular Epidemiology in Diabetes, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.
J Diabetes Investig. 2025 Jul;16(7):1173-1190. doi: 10.1111/jdi.70095. Epub 2025 Jun 10.
There is increasing interest in the implementation of precision medicine in diabetes. Gender is an important determinant of health, and there are numerous characteristics of diabetes in women that can be taken into account for the implementation of precision medicine in diabetes. Furthermore, better appreciation of the unique clinical characteristics of diabetes in women, especially in relation to the lifecourse perspective of a woman's life, would greatly enhance public health efforts to address diabetes and its associated risk factors, and to improve the lives of women and the next generation. These include the unique challenges and opportunities linked with polycystic ovary syndrome, gestational diabetes, other pregnancy complications including preeclampsia, and the potential impact of these diagnoses in the offspring of affected women. In this review article, we will summarize some of these key aspects of how diabetes intersects with women's health, and how a holistic, integrative, and lifecourse approach to diabetes and women's health can have a significant impact well beyond just the benefits of achieving better glucose control for the women living with diabetes, but more importantly, toward improved prevention and control of noncommunicable diseases on a population level.
糖尿病领域对精准医学的实施兴趣日益浓厚。性别是健康的重要决定因素，女性糖尿病存在诸多特征，在糖尿病精准医学实施中可予以考虑。此外，更好地认识女性糖尿病的独特临床特征，尤其是从女性生命历程的角度来看，将极大地加强公共卫生应对糖尿病及其相关危险因素的努力，并改善女性及其下一代的生活。这些包括与多囊卵巢综合征、妊娠期糖尿病、包括先兆子痫在内的其他妊娠并发症相关的独特挑战和机遇，以及这些诊断对受影响女性后代的潜在影响。在这篇综述文章中，我们将总结糖尿病与女性健康相互交叉的一些关键方面，以及对糖尿病和女性健康采取整体、综合和生命历程方法如何不仅能为糖尿病女性带来更好的血糖控制益处，更重要的是，在人群层面朝着改善非传染性疾病的预防和控制产生重大影响。
