Wilson D J, Gentry P A
Toxicol Appl Pharmacol. 1985 Jun 15;79(1):159-65. doi: 10.1016/0041-008x(85)90378-3.
An in vitro bovine ear perfusion system was used to examine the effect of T-2 toxin on peripheral vasculature. T-2 toxin caused a dose-related increase in the perfusion pressure, with an apparent threshold concentration of 1 X 10(-5) M. The effect of the toxin was observed irrespective of the presence of either histamine or norepinephrine in the system. The presence of known histaminic or noradrenergic antagonists did not affect the response to the toxin. Once the vessel was exposed to T-2 toxin, the response to histamine or norepinephrine was decreased.
利用体外牛耳灌注系统研究T-2毒素对外周血管系统的影响。T-2毒素导致灌注压力呈剂量相关增加，明显阈值浓度为1×10⁻⁵ M。无论系统中是否存在组胺或去甲肾上腺素，均可观察到毒素的作用。已知的组胺能或去甲肾上腺素能拮抗剂的存在并不影响对毒素的反应。一旦血管暴露于T-2毒素，对组胺或去甲肾上腺素的反应就会降低。
