Eghianruwa K I, Eyre P
Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada.
Vet Res Commun. 1992;16(5):345-54. doi: 10.1007/BF01839184.
The responses of the vasculature of isolated, non-sensitized, bovine external ears to histamine and serotonin (5-HT) were evaluated while they were being perfused with Krebs-Henseleit solution. Histamine (10(-5) mol/L to 5 x 10(-3) mol/L) and 5-hydroxytryptamine (5-HT) (10(-9) mol/L to 10(-2) mol/L) caused increased vascular resistance. Mepyramine (10(-7) mol/L), cimetidine (10(-5) mol/L) and atropine (10(-6) mol/L) inhibited the responses to histamine. The responses to 5-HT were inhibited by methysergide (10(-9) mol/L) and potentiated by morphine (10(-5) mol/L). These results suggest the presence of H1 and H2 histamine, and 5-HT receptors in bovine auricular vessels, all of which cause net vasoconstriction.
在用克雷布斯 - 亨泽莱特溶液灌注时，对分离的、未致敏的牛外耳血管对组胺和5 - 羟色胺（5 - HT）的反应进行了评估。组胺（10⁻⁵摩尔/升至5×10⁻³摩尔/升）和5 - 羟色胺（5 - HT）（10⁻⁹摩尔/升至10⁻²摩尔/升）导致血管阻力增加。甲氧苄胺（10⁻⁷摩尔/升）、西咪替丁（10⁻⁵摩尔/升）和阿托品（10⁻⁶摩尔/升）抑制了对组胺的反应。对5 - HT的反应被麦角新碱（10⁻⁹摩尔/升）抑制，并被吗啡（10⁻⁵摩尔/升）增强。这些结果表明牛耳血管中存在H1和H2组胺以及5 - HT受体，所有这些都会导致净血管收缩。
