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Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential.

作者信息

Dellar Elizabeth R, Nikel Lara, Fowler Stephanie, Vahsen Björn F, Dafinca Ruxandra, Feneberg Emily, Talbot Kevin, Turner Martin R, Thompson Alexander G

机构信息

Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing John Radcliffe Hospital, OX3 9DU, Oxford, UK.

Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.

出版信息

Mol Neurodegener. 2025 Jun 10;20(1):68. doi: 10.1186/s13024-025-00859-4.

DOI:10.1186/s13024-025-00859-4
PMID:40495245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12153176/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207c/12153176/e8e976f18938/13024_2025_859_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207c/12153176/7a916075c6c5/13024_2025_859_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207c/12153176/e8e976f18938/13024_2025_859_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207c/12153176/7a916075c6c5/13024_2025_859_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207c/12153176/e8e976f18938/13024_2025_859_Fig2_HTML.jpg

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Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential.TDP-43蛋白病中的细胞外囊泡:发病机制及生物标志物潜力
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本文引用的文献

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Integrin beta 1 and fibronectin mediate extracellular vesicle uptake and functional RNA delivery.整合素β1和纤连蛋白介导细胞外囊泡摄取及功能性RNA递送。
J Biol Chem. 2025 Mar;301(3):108305. doi: 10.1016/j.jbc.2025.108305. Epub 2025 Feb 11.
2
Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB.人类 VCP 突变型 ALS/FTD 小胶质细胞表现出免疫和溶酶体表型,与 GPNMB 无关。
Mol Neurodegener. 2024 Nov 26;19(1):90. doi: 10.1186/s13024-024-00773-1.
3
Measurement of α-synuclein as protein cargo in plasma extracellular vesicles.
血浆细胞外囊泡中α-突触核蛋白作为蛋白货物的测量。
Proc Natl Acad Sci U S A. 2024 Nov 5;121(45):e2408949121. doi: 10.1073/pnas.2408949121. Epub 2024 Oct 30.
4
Associations of age and sex with characteristics of extracellular vesicles and protein-enriched fractions of blood plasma.年龄和性别与细胞外囊泡及血浆富含蛋白质组分特征的关联。
Aging Cell. 2025 Jan;24(1):e14356. doi: 10.1111/acel.14356. Epub 2024 Oct 7.
5
Location and function of TDP-43 in platelets, alterations in neurodegenerative diseases and arising considerations for current plasma biobank protocols.TDP-43 在血小板中的位置和功能、神经退行性疾病中的改变,以及对当前血浆生物库协议的新考虑。
Sci Rep. 2024 Sep 18;14(1):21837. doi: 10.1038/s41598-024-70822-8.
6
A microRNA diagnostic biomarker for amyotrophic lateral sclerosis.一种用于肌萎缩侧索硬化症的微小RNA诊断生物标志物。
Brain Commun. 2024 Sep 13;6(5):fcae268. doi: 10.1093/braincomms/fcae268. eCollection 2024.
7
Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes.小胶质细胞通过形成隧道纳米管来挽救聚集诱导的神经元功能障碍和死亡。
Neuron. 2024 Sep 25;112(18):3106-3125.e8. doi: 10.1016/j.neuron.2024.06.029. Epub 2024 Jul 25.
8
Proteomic insights into extracellular vesicles in ALS for therapeutic potential of Ropinirole and biomarker discovery.对肌萎缩侧索硬化症细胞外囊泡的蛋白质组学见解,用于罗匹尼罗的治疗潜力及生物标志物发现。
Inflamm Regen. 2024 Jul 12;44(1):32. doi: 10.1186/s41232-024-00346-1.
9
Unpacking extracellular vesicles: RNA cargo loading and function.解析细胞外囊泡:RNA 货物装载与功能
J Extracell Biol. 2022 May 2;1(5):e40. doi: 10.1002/jex2.40. eCollection 2022 May.
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ELISA-based detection of immunoglobulins against extracellular vesicles in blood plasma.基于酶联免疫吸附测定法检测血浆中针对细胞外囊泡的免疫球蛋白
J Extracell Biol. 2024 Mar 7;3(3):e129. doi: 10.1002/jex2.129. eCollection 2024 Mar.