Banks J, Jenkins P A, Smith A P
Tubercle. 1985 Sep;66(3):197-203. doi: 10.1016/0041-3879(85)90037-6.
Thirty seven patients whose sputum cultures had yielded positive isolates of Mycobacterium malmoense during the years 1978-1983 have been reviewed. Significant pulmonary infection was present in 34 patients (92%), 3 of whom had only single isolates cultured from their sputum. The significance of isolates in the remaining 3 patients was not established. There was pre-existing pulmonary disease in 22 patients and another 4 were taking immuno-suppressive drugs. Various drug regimens were used to treat the condition but the best responses were seen in 5 patients (13.5%) who received 3 standard drugs given for between 18-24 months. Relapse occurred in 3 of another 5 who were treated with the same combination but given for less than 18 months. Omission of ethambutol from this standard regimen was associated with an unfavourable course in another 7 patients. Regimens which included the second line drugs ethionamide and cycloserine were given to 10 patients. The responses in this group were poor and were probably related to drug toxicity and poor patient compliance. Four of these patients eventually underwent successful resectional surgery.
对1978年至1983年间痰培养出马尔默分枝杆菌阳性菌株的37例患者进行了回顾性研究。34例患者（92%）存在严重肺部感染，其中3例患者痰培养仅分离出单一菌株。其余3例患者分离菌株的意义尚未明确。22例患者既往有肺部疾病，另有4例正在服用免疫抑制药物。采用了各种药物治疗方案，但5例患者（13.5%）接受3种标准药物治疗18至24个月，疗效最佳。另外5例接受相同联合用药但治疗时间不足18个月的患者中有3例复发。在另外7例患者中，该标准方案中省略乙胺丁醇与病情进展不利有关。10例患者使用了包括二线药物乙硫异烟胺和环丝氨酸的治疗方案。该组患者反应较差，可能与药物毒性和患者依从性差有关。其中4例患者最终接受了成功的切除手术。
