Zhongling Ke, Mengxin Chen, Yuxian Huang, Yanhui Chen
Department of Pediatrics, Fujian Medical University Union Hospital, Fuzhou, China.
Brain Behav. 2025 Jun;15(6):e70617. doi: 10.1002/brb3.70617.
This study aims to investigate cerebrospinal fluid (CSF) in patients with Tourette syndrome (TS) to identify the role of neuroinflammation in the pathophysiology of TS.
We retrospectively reported cerebrospinal fluid (CSF) examination in four male adolescents diagnosed with severe TS, as indicated by a high Yale Global Tic Severity Scale (YGTSS) score. The examination included routine and biochemical tests, oligoclonal band testing, and analysis of 14 neural autoantibodies. Furthermore, the levels of 34 cytokines were also measured.
CSF examinations revealed that routine and biochemical tests were normal and that no oligoclonal bands were detected. The 14 neural autoantibodies tested were negative. Among the 34 cytokines analyzed, only monocyte chemoattractant protein-1 (MCP-1) levels were significantly elevated.
This study is the first to report elevated levels of MCP-1 in the CSF of patients with TS. Our findings suggest that MCP-1-associated neuroinflammation may play a crucial role in the pathogenesis of TS, indicating that targeting MCP-1 could be a promising therapeutic approach to managing symptoms of TS.
本研究旨在调查抽动秽语综合征（TS）患者的脑脊液（CSF），以确定神经炎症在TS病理生理学中的作用。
我们回顾性报告了4名被诊断为重度TS的男性青少年的脑脊液（CSF）检查情况，其耶鲁全球抽动严重程度量表（YGTSS）得分较高。检查包括常规和生化检测、寡克隆带检测以及14种神经自身抗体分析。此外，还测量了34种细胞因子的水平。
脑脊液检查显示常规和生化检测正常，未检测到寡克隆带。所检测的14种神经自身抗体均为阴性。在分析的34种细胞因子中，只有单核细胞趋化蛋白-1（MCP-1）水平显著升高。
本研究首次报告了TS患者脑脊液中MCP-1水平升高。我们的研究结果表明，与MCP-1相关的神经炎症可能在TS的发病机制中起关键作用，这表明针对MCP-1可能是一种治疗TS症状的有前景的治疗方法。
