Clinic of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.
Mov Disord. 2011 Feb 1;26(2):343-6. doi: 10.1002/mds.23403. Epub 2010 Oct 19.
Since a postinfectious or autoimmune etiology is suggested to be involved in the pathogenesis of Tourette's syndrome (TS), we investigated oligoclonal bands (OB) of immunoglobulin G (IgG) in cerebrospinal fluid (CSF), indicating a humoral immune response in the central nervous system. CSF examinations including isoelectric focusing to analyze the presence of OB were performed in 21 TS patients [17 men/4 women, mean age = 29 ± 12 (SD) years]. Isoelectric focusing showed the presence of positive OB in 6, borderline bands in 2, and serum and CSF bands ("mirrored pattern") in another 2 patients. Clinical data did not correlate with CSF findings. Thus, 38% (8 of 21) of our patients exhibited pathological CSF bands. Since none of them suffered from another disease known to be associated with OB, our results suggest an association with the pathogenesis of TS itself and point to an involvement of immunological mechanisms in TS pathology.
由于提示感染后或自身免疫性病因与妥瑞氏综合征（TS）的发病机制有关，我们研究了中枢神经系统体液免疫反应的脑脊液（CSF）中免疫球蛋白 G（IgG）的寡克隆带（OB）。21 例 TS 患者[17 名男性/4 名女性，平均年龄=29±12（SD）岁]进行了包括等电聚焦以分析 OB 存在的 CSF 检查。等电聚焦显示 6 例阳性 OB、2 例边界带和另外 2 例血清和 CSF 带（“镜像模式”）。临床数据与 CSF 结果不相关。因此，我们的患者中有 38%（21 例中的 8 例）出现病理性 CSF 带。由于他们均未患有其他已知与 OB 相关的疾病，我们的结果提示与 TS 本身的发病机制有关，并表明免疫机制参与了 TS 病理学。
