Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China; Fundamental Research Center, Department of Neurology and Neurological Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Neurosci Biobehav Rev. 2022 Jan;132:362-377. doi: 10.1016/j.neubiorev.2021.12.004. Epub 2021 Dec 6.
This systematic review aims to 1) explore the association between tic disorders (TD) and allergic diseases (AD), 2) judge whether patients with a diagnosis of TD are prone to suffer from a specific AD, by compiling the literature and analyzing the evidence. A literature search was conducted in PubMed and Embase database on February 24, 2021. The inclusion criteria for the literature were all comparative studies that reported TD patients were diagnosed with allergic illness as well. We identified that TD is positively associated with asthma, allergic rhinitis and allergic conjunctivitis, respectively. Especially, provisional tic disorder (PTD) patients might be more likely to suffer from these three AD, although it is still difficult to accurately predict which specific AD is prone to be accompanied by a specific TD. Shared genetic and etiological factors are suggested responsible for the AD-TD association. Large prospective cohort studies in future might shed light on a deep understanding of the relationship between immune disorders and tics.
1）探索抽动障碍（TD）与过敏性疾病（AD）之间的关联；2）通过文献汇编和证据分析，判断诊断为 TD 的患者是否易患特定的 AD。于 2021 年 2 月 24 日在 PubMed 和 Embase 数据库中进行了文献检索。文献纳入标准为所有报告 TD 患者同时被诊断为过敏性疾病的对照研究。我们发现 TD 分别与哮喘、过敏性鼻炎和过敏性结膜炎呈正相关。特别是，暂时性抽动障碍（PTD）患者可能更容易患这三种 AD，尽管仍然难以准确预测哪种特定的 AD 易伴发特定的 TD。提示共同的遗传和病因因素可能与 AD-TD 关联有关。未来的大型前瞻性队列研究可能有助于深入了解免疫紊乱与抽动之间的关系。
