Benlioğlu Can, Aydın Yunus, Bostancı Mehmet Sühha, Bozdağ Gürkan, Bulgurcuoğlu Sibel, Demir Ahmet, Dilbaz Serdar, Dirican Enver Kerem, Erdem Ahmet, Ergin Elif, Göksever Çelik Hale, Güler İsmail, Gürbüz Ali Sami, Işıkoğlu Mete, Kahraman Semra, Mumuşoğlu Sezcan, Özgür Kemal, Şimşek Erhan, Şükür Yavuz Emre, Turan Volkan, Uncu Gürkan, Urman Bülent, Ünsal Evrim, Balaban Başak, Ata Barış
Department of Obstetrics and Gynecology and Assisted Reproduction, Koç University Hospital, İstanbul, Türkiye.
Clinic of Obstetrics and Gynecology, Private Sağlık Hospital IVF Centre, Denizli, Türkiye.
J Turk Ger Gynecol Assoc. 2025 Jun 10;26(2):109-115. doi: 10.4274/jtgga.galenos.2025.2025-2-1.
To investigate patient characteristics and outcomes of assisted reproductive technology (ART) cycles conducted in Türkiye during the coronavirus disease-2019 (COVID-19) pandemic (2020-2021).
ART centers in Türkiye were invited to participate in this survey. The questionnaire focused on patient demographics and performance outcomes and was sent to center directors via anonymous Qualtrics™ links.
The survey was sent to 167 centers and data were collected from 15 centers in 2020 and 24 centers in 2021. The clinical pregnancy rate from intrauterine insemination (IUI) procedures remained similar, with 15.1% in 2020 (1,245 IUI cycles) and 14.5% in 2021 (2,023 IUI cycles), while successful delivery rates were 12.5% and 11.5%, respectively. For ART treatments, the clinical pregnancy rate from fresh embryo transfers increased from 45.1% in 2020 (3,119 transfers) to 50.4% in 2021 (8832 transfers), with similar live birth rates, 34.2% vs. 34.4%. Frozen embryo transfers resulted in clinical pregnancy rates of 47.8% in 2020 (2,498 transfers) and 51.9% in 2021 (12,015 transfers), with live birth rates rising from 39.8% to 42.7%. Preimplantation genetic testing cycles resulted in clinical pregnancy rates of 64.2% in 2020 (271 transfers) and 60.8% in 2021 (2,102 transfers), with live birth rates of 53.5% and 48.2%, respectively. Regarding techniques for fertility preservation in females, 11 prepubertal and 61 postpubertal ovarian tissue cryopreservation procedures were reported, alongside 1,346 cycles performed within the same period. In males, 144 post-pubertal testicular tissue, 871 epididymal and 2,480 ejaculated sperm cryopreservations were reported. During the two years, six ovarian tissue transplantations followed by ART were performed, with 96 women using cryopreserved oocytes. In addition, 40 testicular tissue, 298 epididymal, and 238 ejaculated sperm samples were used for ART purposes.
This survey provides a comprehensive overview of ART practices in Türkiye for 2020 and 2021, establishing a long-term, nationallevel analysis while highlighting the challenges posed by the COVID-19 pandemic. The longitudinal analysis established a foundation for future annual reports and offers critical insights into emerging trends over these two years.
调查2019年冠状病毒病（COVID-19）大流行期间（2020 - 2021年）在土耳其进行的辅助生殖技术（ART）周期的患者特征和结局。
邀请土耳其的ART中心参与本调查。问卷聚焦于患者人口统计学和治疗结局，并通过匿名的Qualtrics™链接发送给中心主任。
该调查发送至167个中心，2020年从15个中心收集到数据，2021年从24个中心收集到数据。宫内人工授精（IUI）程序的临床妊娠率保持相似，2020年为15.1%（1245个IUI周期），2021年为14.5%（2023个IUI周期），而成功分娩率分别为12.5%和11.5%。对于ART治疗，新鲜胚胎移植的临床妊娠率从2020年的45.1%（3119次移植）升至2021年的50.4%（8832次移植），活产率相似，分别为34.2%和34.4%。冷冻胚胎移植的临床妊娠率在2020年为47.8%（2498次移植），2021年为51.9%（12015次移植），活产率从39.8%升至42.7%。植入前基因检测周期的临床妊娠率在2020年为64.2%（271次移植），2021年为60.8%（2102次移植），活产率分别为53.5%和48.2%。关于女性生育力保存技术，报告了11例青春期前和61例青春期后卵巢组织冷冻保存程序，以及同期进行的1346个周期。在男性中，报告了144例青春期后睾丸组织、871例附睾和2480例射精精子冷冻保存。在这两年中，进行了6例卵巢组织移植后行ART，96名女性使用了冷冻卵母细胞。此外，40例睾丸组织、298例附睾和238例射精精子样本用于ART目的。
本调查全面概述了2020年和2021年土耳其的ART实践，建立了长期的国家级分析，同时突出了COVID-19大流行带来的挑战。纵向分析为未来的年度报告奠定了基础，并提供了这两年新趋势的关键见解。
