Zhang Miao, Hu Jialin, Zhang Yaoyu, Meng Ziyu, Zhao Yibo, Li Yudu, Jin Wen, Qian Xiao-Hang, Wang Lijun, Ye Guanyu, Jiang Xu-Feng, Li Ya-Dong, Ye Jian, Tang Huidong, Liu Jun, Nachev Parashkev, Liang Zhi-Pei, Li Biao, Li Yao
Department of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
National Engineering Research Center of Advanced Magnetic Resonance Technologies for, Diagnosis and Therapy, Shanghai Jiao Tong University, Shanghai, China.
Alzheimers Dement. 2025 Jun;21(6):e70332. doi: 10.1002/alz.70332.
Understanding the neurometabolic changes associated with amyloid-β (Aβ) deposition is important for early Alzheimer's disease (AD) diagnosis, but their spatial relationships remained unexplored due to technical limitations.
We investigated the relationship between Aβ deposition and neuronal and glial metabolites using high-resolution 3D magnetic resonance spectroscopic imaging (MRSI) (8-min scan, 2 × 3 × 3 mm resolution) and Aβ-positron emission tomography (Aβ-PET) imaging. N-acetylaspartate, myo-inositol, and creatine maps were obtained from 174 participants: 39 controls, 65 mild cognitive impairment (MCI), and 70 AD patients.
N-Acetylaspartate levels were negatively correlated with Aβ, while myo-inositol levels were positively correlated globally. Regional associations with Aβ include N-acetylaspartate reductions in frontal cortex, anterior cingulate cortex, and precuneus, and myo-inositol increases in precuneus, lateral temporal, and lateral parietal cortices. Combined MRSI and PET biomarkers achieved the highest diagnostic accuracy for MCI and AD .
Hybrid high-resolution 3D MRSI and Aβ-PET imaging provides valuable insights into Aβ's impact on neurometabolic changes, improving early AD diagnosis.
Hybrid 3D magnetic resonance spectroscopic imaging-positron emission tomography (MRSI-PET) imaging reveals Aβ deposition impact on neurometabolism in Alzheimer's disease (AD). N-acetylaspartate (NAA) as a neuronal metabolic marker is negatively associated with Aβ globally and locally. Myo-inositol (mI) as a glial metabolic marker is positively associated with Aβ globally and locally. Combining 3D magnetic resonance spectroscopic imaging (MRSI) and PET biomarkers improves diagnostic accuracy for mild cognitive impairment (MCI) and AD.
了解与淀粉样β蛋白（Aβ）沉积相关的神经代谢变化对于早期阿尔茨海默病（AD）诊断至关重要，但由于技术限制，它们的空间关系仍未得到探索。
我们使用高分辨率3D磁共振波谱成像（MRSI）（8分钟扫描，2×3×3毫米分辨率）和Aβ正电子发射断层扫描（Aβ-PET）成像研究了Aβ沉积与神经元和神经胶质代谢物之间的关系。从174名参与者中获得了N-乙酰天门冬氨酸、肌醇和肌酸图谱，其中包括39名对照者、65名轻度认知障碍（MCI）患者和70名AD患者。
N-乙酰天门冬氨酸水平与Aβ呈负相关，而肌醇水平总体上呈正相关。与Aβ的区域关联包括额叶皮质、前扣带回皮质和楔前叶中N-乙酰天门冬氨酸减少，以及楔前叶、颞叶外侧和顶叶外侧皮质中肌醇增加。联合MRSI和PET生物标志物对MCI和AD的诊断准确性最高。
混合高分辨率3D MRSI和Aβ-PET成像为Aβ对神经代谢变化的影响提供了有价值的见解，提高了AD的早期诊断水平。
混合3D磁共振波谱成像-正电子发射断层扫描（MRSI-PET）成像揭示了Aβ沉积对阿尔茨海默病（AD）神经代谢的影响。N-乙酰天门冬氨酸（NAA）作为神经元代谢标志物在整体和局部上均与Aβ呈负相关。肌醇（mI）作为神经胶质代谢标志物在整体和局部上均与Aβ呈正相关。结合3D磁共振波谱成像（MRSI）和PET生物标志物可提高轻度认知障碍（MCI）和AD的诊断准确性。
