青霉素对灰色链霉菌产生链霉素的影响。
Effect of penicillin on streptomycin production by Streptomyces griseus.
作者信息
Barabas G Y, Szabó G
出版信息
Antimicrob Agents Chemother. 1977 Mar;11(3):392-5. doi: 10.1128/AAC.11.3.392.
Abstract
The correlation between the biosynthesis of the cell wall and the formation of streptomycin (SM) in Streptomyces griseus, influenced by a specific inhibitor of cell wall synthesis, was investigated. Penicillin, in subinhibitory concentrations (1 to 5 mug/ml), was added to cultures of S. griseus in different stages of its life cycle. The inhibitor decreased SM production, when young cultures were treated; however, there was an increase in SM formation when penicillin was added to older cultures. The explanation for these findings is discussed in detail.
摘要
研究了细胞壁合成的生物合成与灰色链霉菌中链霉素（SM）形成之间的相关性，该相关性受细胞壁合成的特异性抑制剂影响。将亚抑制浓度（1至5微克/毫升）的青霉素添加到处于其生命周期不同阶段的灰色链霉菌培养物中。当处理年轻培养物时，该抑制剂会降低SM的产量；然而，当将青霉素添加到较老的培养物中时，SM的形成会增加。对这些发现的解释进行了详细讨论。
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