Harsha P S, Jayadevan Jinesh, Haris C H, Thomas Rajiv, Balabhaskar H, Aiyappan Ramkumar, Shaneej M Sharoo
Department of Urology, Government Medical College, Trivandrum, India.
Urol Case Rep. 2025 May 15;61:103065. doi: 10.1016/j.eucr.2025.103065. eCollection 2025 Jul.
Stauffer syndrome is a rare paraneoplastic syndrome associated with Renal Cell Cancer (RCC), seen in 3 %-20 % of cases characterized by reversible nonmetastatic anicteric, hepatic dysfunction in the absence of direct hepatobiliary obstruction. We report a case of 78-yr old male, post Whipple surgery who presented with progressive and isolated elevation of Aminotransferases. Imaging confirmed the presence of a renal mass without hepatic metastasis. The patient underwent partial nephrectomy. The patient's clinical course, management, and subsequent resolution of hepatic dysfunction after resection underscore the importance of considering Stauffer syndrome in patients with unexplained liver test abnormalities.
施陶费尔综合征是一种与肾细胞癌（RCC）相关的罕见副肿瘤综合征，在3% - 20%的病例中可见，其特征为在无直接肝胆梗阻的情况下出现可逆性非转移性无黄疸性肝功能障碍。我们报告一例78岁男性患者，在惠普尔手术后出现进行性且孤立性的转氨酶升高。影像学检查证实存在肾脏肿块且无肝转移。该患者接受了部分肾切除术。患者的临床病程、治疗以及切除术后肝功能障碍的后续缓解强调了在不明原因肝功能检查异常的患者中考虑施陶费尔综合征的重要性。
