Rafeie Niyousha, Salimi Yasaman, Aghamir Zahra Sadat, Amini Amirhesam, Taheri Hamed, Sadreddini Sarvin, Kamali Fatemeh, Akbarian Golnesa, Azizi Nazanin, Bagherianlemraski Mobina, Valizadeh Maryam, Alimohammadi Farnoosh, Sedighnia Negar, Qadirifard Mohammad, Naziri Mahdyieh
Department of Biomaterials and Biomimetics, Division of Biomaterials, College of Dentistry, New York University, New York, NY, United States.
Department of Periodontics, School of Dentistry, Guilan University of Medical Sciences, Rasht, Iran.
Front Oral Health. 2025 May 27;6:1484364. doi: 10.3389/froh.2025.1484364. eCollection 2025.
BACKGROUND/PURPOSE: The present study aimed to evaluate the effect of pomegranate extract on the prevention of dental caries compared to standard care, placebo, and no intervention.
A bibliographic search in four databases, including PubMed, Scopus, Google Scholar, and CENTRAL, yielded 291 studies until September 8, 2023. The search was performed among the studies written in English using the search terms "" AND ("dental caries" OR "" OR "tooth demineralization") After screening the titles/abstracts and full texts of these studies, 7 articles were chosen.
In all 7 articles, pomegranate mouthwash was used as the intervention. In 5 studies, the control group used 0.2% chlorhexidine (CHX) mouthwash. Additionally, 4 articles reported a reduction in the mean plaque count in both groups; however, better results were observed in the CHX mouthwash group. In one study, no significant difference was reported between the study and control groups. Finally, one study showed the significant superiority of a hydroalcoholic extract of pomegranate mouthwash over CHX mouthwash.
Overall, the results suggest that pomegranate extract mouthwash is highly effective in reducing caries-causing bacteria. No side effects were reported for pomegranate use in these studies.
背景/目的：本研究旨在评估与标准护理、安慰剂和无干预措施相比，石榴提取物在预防龋齿方面的效果。
在四个数据库（包括PubMed、Scopus、谷歌学术和CENTRAL）中进行文献检索，截至2023年9月8日共检索到291项研究。使用检索词“”以及（“龋齿”或“”或“牙齿脱矿”）在英文撰写的研究中进行检索。在筛选这些研究的标题/摘要和全文后，选择了7篇文章。
在所有7篇文章中，均使用石榴漱口水作为干预措施。在5项研究中，对照组使用0.2%氯己定（CHX）漱口水。此外，4篇文章报告两组的平均菌斑计数均有所减少；然而，CHX漱口水组的效果更好。在一项研究中，研究组和对照组之间未报告有显著差异。最后，一项研究表明石榴漱口水的水醇提取物优于CHX漱口水。
总体而言，结果表明石榴提取物漱口水在减少致龋细菌方面非常有效。在这些研究中，未报告使用石榴有任何副作用。
