Elling F, Pedersen K B
Vet Pathol. 1985 Sep;22(5):469-74. doi: 10.1177/030098588502200506.
Six one-week-old piglets were pretreated with a 1% acetic acid solution for two days in one or both nostrils. Three piglets were not treated with acetic acid. Three days after treatment all nine piglets were inoculated in both nostrils with a toxigenic type D strain of Pasteurella multocida. Three piglets were killed seven days after inoculation; one died spontaneously 13 days after inoculation and the remaining pigs were killed at approximately 90 kg body weight, i.e., five to six months of age. All acetic acid-treated animals developed severe atrophy of the turbinates in the treated nostrils. Untreated nostrils were normal. The present results showed that toxigenic P. multocida can induce turbinate atrophy that persisted until 90 kg body weight when the lesions were similar to spontaneous atrophic rhinitis in pigs. The turbinate atrophy was not accompanied by inflammatory reaction, atrophy of other bone structures, or lesions in other organs. The experiment showed furthermore that toxigenic P. multocida may be present in the tonsils of control animals without causing turbinate atrophy. A pathogenesis for atrophic rhinitis in pigs is proposed.
六只一周龄仔猪在一个或两个鼻孔中用1%醋酸溶液预处理两天。三只仔猪未用醋酸处理。处理三天后，所有九只仔猪都在两个鼻孔中接种了产毒素的多杀性巴氏杆菌D型菌株。三只仔猪在接种后七天被处死；一只在接种后13天自然死亡，其余仔猪在体重约90公斤时，即五到六个月龄时被处死。所有经醋酸处理的动物，其处理过的鼻孔中的鼻甲都出现了严重萎缩。未处理的鼻孔正常。目前的结果表明，产毒素的多杀性巴氏杆菌可诱发鼻甲萎缩，这种萎缩一直持续到90公斤体重时，此时病变与猪的自发性萎缩性鼻炎相似。鼻甲萎缩不伴有炎症反应、其他骨骼结构的萎缩或其他器官的病变。该实验还表明，产毒素的多杀性巴氏杆菌可能存在于对照动物的扁桃体中，但不会引起鼻甲萎缩。本文提出了猪萎缩性鼻炎的发病机制。
