Harjola Pia, Harjola Veli-Pekka, Miró Òscar, Laribi Said, Tarvasmäki Tuukka
Emergency Medicine, University of Helsinki and Department of Emergency Medicine and Services, Helsinki University Hospital, Helsinki, Finland.
Emergency Department, Hospital Clínic, University of Barcelona, Catalonia, Spain.
Clin Cardiol. 2025 Jun;48(6):e70161. doi: 10.1002/clc.70161.
The prognosis of acute heart failure (AHF) remains poor. Studies focusing on the time-sensitivity of early AHF management have reported controversial results. Thus, our aim is to review current studies focusing on AHF patients using emergency medical services (EMS), their early management, and patient outcomes.
We searched the recent literature in PubMed and Scopus for studies comparing AHF patients arriving at the hospital by EMS to those self-presenting (non-EMS) at ED (emergency department) from database inception until November 2022.
The literature search found five studies fulfilling our inclusion criteria. The percentage of AHF patients using EMS varied in these studies: 11.5% (100/873) in Finnish FINN-AKVA II, 22.1% (236/1068) in Canadian ASCEND-HF, 35.5% (5129/14454) in a Pakistan Heart Failure-registry study, 52.8% (3224/6106) in Spanish SEMICA, and 61.8% (309/500) in the European EURODEM study. The pre-hospital management differed across the reviewed studies. The use of NIV was rare, ranging from zero to four percent. Vasodilators and diuretics were more commonly used. Although, the differences in the use were obvious (range from 7.1% to 22.0%, and 0.0% to 29.0% accordingly). Three of the studies reported significantly higher 30-day mortality among EMS patients compared to non-EMS patients: ranging from 5.6% versus 3.5%, p < 0.001% to 15.0% versus 6.9%, p < 0.001.
The use of EMS, as well as pre-hospital management, varies between the international cohorts and registries. The pre-hospital AHF management is generally limited. Moreover, EMS patients tend to have worse outcomes compared to non-EMS patients.
急性心力衰竭(AHF)的预后仍然很差。关注早期AHF管理时间敏感性的研究报告了相互矛盾的结果。因此,我们的目的是回顾当前针对使用紧急医疗服务(EMS)的AHF患者、其早期管理及患者结局的研究。
我们在PubMed和Scopus中检索了近期文献,以查找从数据库建立至2022年11月期间,比较通过EMS送至医院的AHF患者与自行前往急诊科(ED)的患者(非EMS患者)的研究。
文献检索发现五项研究符合我们的纳入标准。这些研究中使用EMS的AHF患者比例各不相同:芬兰FINN-AKVA II研究中为11.5%(100/八百七十三),加拿大ASCEND-HF研究中为22.1%(236/一千零六十八),巴基斯坦心力衰竭登记研究中为35.5%(5129/一万四千四百五十四),西班牙SEMICA研究中为52.8%(3224/六千一百零六),欧洲EURODEM研究中为61.8%(309/五百)。各综述研究的院前管理有所不同。无创通气(NIV)的使用很少,范围从零至4%。血管扩张剂和利尿剂使用更为普遍。不过,使用差异较为明显(分别为7.1%至22.0%和0.0%至29.0%)。三项研究报告称,与非EMS患者相比,EMS患者30天死亡率显著更高:范围从5.6%对3.5%,p<0.001%至15.0%对6.9%,p<0.001。
国际队列和登记研究中EMS的使用以及院前管理各不相同。院前AHF管理普遍有限。此外,与非EMS患者相比,EMS患者的结局往往更差。