长链非编码 RNA 与胃癌：潜在生物标志物和治疗应用的最新研究进展。
Long non-coding RNAs and gastric cancer: An update of potential biomarkers and therapeutic applications.
机构信息
Department of Medical Biotechnology, School of Advanced Technology, Shahrekord University of Medical Sciences, Shahrekord, Iran; Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran; USERN office, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.
出版信息
Biomed Pharmacother. 2023 Jul;163:114407. doi: 10.1016/j.biopha.2023.114407. Epub 2023 Apr 24.
The frequent metastasis of gastric cancer (GC) complicates the cure and therefore the development of effective diagnostic and therapeutic approaches is urgently necessary. In recent years, lncRNA has emerged as a drug target in the treatment of GC, particularly in the areas of cancer immunity, cancer metabolism, and cancer metastasis. This has led to the demonstration of the importance of these RNAs as prognostic, diagnostic and therapeutic agents. In this review, we provide an overview of the biological activities of lncRNAs in GC development and update the latest pathological activities, prognostic and diagnostic strategies, and therapeutic options for GC-related lncRNAs.
胃癌（GC）经常发生转移，使治愈变得复杂，因此迫切需要开发有效的诊断和治疗方法。近年来，lncRNA 已成为治疗 GC 的药物靶点，特别是在癌症免疫、癌症代谢和癌症转移领域。这证明了这些 RNA 作为预后、诊断和治疗剂的重要性。在这篇综述中，我们概述了 lncRNA 在 GC 发展中的生物学活性，并更新了与 GC 相关 lncRNA 的最新病理活性、预后和诊断策略以及治疗选择。
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