Doroshenko N V, Zhylkylbaev E Zh, Zhilina N N, Kelli E I, Braginskiĭ D M
Vopr Virusol. 1985 May-Jun;30(3):333-7.
The use of specific sensitive methods for demonstration of hepatitis A markers has made it possible to detect 6 children with inapparent form of the disease among 86 subjects present in the focus of infection. Specific HAV antibody of the M class were detected in 100% of them. By radioimmunoassay, hepatitis A virus antigen (HAV-Ag) was detected in fecal extracts in 1 case only. Liver biopsy from 1 patient with inapparent disease showed typical morphological signs of acute hepatitis, and HAV-Ag was detected in the hepatocyte cytoplasm by immunofluorescence. Titres of specific antibody in convalescence varied from 1:10 to 1:800 in patients with the inapparent forms and from 1:200 to 1:3200 in manifest forms of hepatitis A.
使用特定的敏感方法来检测甲型肝炎标志物，使得在感染源中的86名受试者中检测出6名患有隐匿型疾病的儿童成为可能。在他们所有人中均检测到了M类特异性甲型肝炎抗体。通过放射免疫测定法，仅在1例粪便提取物中检测到甲型肝炎病毒抗原（HAV-Ag）。1例隐匿型疾病患者的肝活检显示出急性肝炎的典型形态学特征，并且通过免疫荧光在肝细胞胞质中检测到了HAV-Ag。隐匿型甲型肝炎患者恢复期的特异性抗体滴度在1:10至1:800之间，而显性甲型肝炎患者的抗体滴度在1:200至1:3200之间。
