Shakhgil'dian I V, Zhylkybaev E Zh, Stakhanova V M, Doroshenko N V, Braginskiĭ D M
Zh Mikrobiol Epidemiol Immunobiol. 1985 Mar(3):56-61.
In 4 foci of hepatitis A (HA) at children's institutions in Moscow 218 children and 30 staff members were examined. Simultaneously with clinico-biochemical studies, specific IgM and IgG in the blood and hepatitis A virus (HAV) antigen in feces were determined by radioimmunoassay. Different forms of HA were detected in 29.1% of children in kindergartens, 19.4% of school children and 3.3% of adults, which was due to great differences in the size of the immune stratum among them (IgG to HAV was detected in 8-10% of children aged 3-6 years and in 83% of adults). In 2/3 of children with HA in the foci the disease was not accompanied by jaundice, 1/5 of them having the inapparent form of this infection. In 45% of the patients HAV antigen was detected in feces, irrespective of the form of HA, 5-14 days before the appearance of hyperfermentemia, and in 2/3 of them this antigen was also detected during the first 6 days after that. Simultaneously with an increase in aminotransferase activity, all of the HA patients showed the presence of specific IgM in their blood.
在莫斯科儿童机构的4个甲型肝炎（HA）疫源地，对218名儿童和30名工作人员进行了检查。在进行临床生化研究的同时，通过放射免疫测定法测定血液中的特异性IgM和IgG以及粪便中的甲型肝炎病毒（HAV）抗原。在幼儿园儿童中，29.1%检测出不同形式的HA；在校学生中，19.4%检测出不同形式的HA；成年人中，3.3%检测出不同形式的HA，这是由于他们之间免疫层大小存在很大差异（3至6岁儿童中8 - 10%检测出抗HAV IgG，成年人中83%检测出抗HAV IgG）。在疫源地患有HA的儿童中，2/3的患儿疾病未伴有黄疸，其中1/5为这种感染的隐性形式。45%的患者在出现高酶血症前5 - 14天，无论HA形式如何，粪便中均检测出HAV抗原，其中2/3的患者在之后的前6天也检测出该抗原。在转氨酶活性升高的同时，所有HA患者血液中均检测出特异性IgM。
