Neves Marta Moura, Ventura Fabiana, Madeira Nuno
Department of Psychiatry and Mental Health, Coimbra Local Health Unit, Coimbra, Portugal.
Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra, Portugal.
Schizophrenia (Heidelb). 2025 Jun 11;11(1):87. doi: 10.1038/s41537-025-00629-7.
Deficits in social cognition are significant barriers to functional living for individuals with schizophrenia. Although these symptoms have garnered increasing research attention, an effective treatment remains elusive. This systematic review evaluates the use of neuromodulation techniques in treating social cognition deficits in schizophrenia.
We conducted a literature search in MEDLINE/PubMed, Web of Science, The Cochrane Library, and Embase databases, adhering to PRISMA guidelines. We included randomized, sham-controlled trials, non-controlled and/or open-label trials that assessed the efficacy of neuromodulation in patients diagnosed with schizophrenia (as per the DSM-III or later editions, or ICD equivalents), aged over 18 years.
Thirteen papers (1 on ECT, 4 on rTMS, and 8 on tES), including 11 RCTs, met the inclusion criteria. Seven of the thirteen analyzed studies indicated improvements in certain domains of social cognition associated with neuromodulation treatments.
Neuromodulation techniques improved some domains of social cognition in individuals with schizophrenia. Further research is required to develop robust treatment protocols with proven efficacy in improving social cognition.
社会认知缺陷是精神分裂症患者功能性生活的重大障碍。尽管这些症状已获得越来越多的研究关注，但有效的治疗方法仍然难以捉摸。本系统评价评估了神经调节技术在治疗精神分裂症社会认知缺陷中的应用。
我们按照PRISMA指南，在MEDLINE/PubMed、科学网、考克兰图书馆和Embase数据库中进行了文献检索。我们纳入了随机、假对照试验、非对照和/或开放标签试验，这些试验评估了神经调节对诊断为精神分裂症（根据DSM-III或更高版本，或等效的ICD）、年龄超过18岁患者的疗效。
13篇论文（1篇关于ECT，4篇关于rTMS，8篇关于tES），包括11项随机对照试验，符合纳入标准。13项分析研究中的7项表明，与神经调节治疗相关的社会认知某些领域有所改善。
神经调节技术改善了精神分裂症患者社会认知的某些领域。需要进一步研究以制定在改善社会认知方面具有已证实疗效的可靠治疗方案。
