Yamada Yuji, Inagawa Takuma, Sueyoshi Kazuki, Sugawara Norio, Ueda Natsuki, Omachi Yoshie, Hirabayashi Naotsugu, Matsumoto Madoka, Sumiyoshi Tomiki
Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Department of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Front Psychiatry. 2019 May 15;10:333. doi: 10.3389/fpsyt.2019.00333. eCollection 2019.
Social cognition deficits are a core feature of schizophrenia and deteriorate functionality of patients. However, evidence is sparse for the treatment effect on social cognition impairments in the early stage of psychosis. Here, we provide a systematic review of the literature on social cognitive impairment in early psychosis in relation to its intervention. A literature search was conducted on English articles identified by Web of Science and PubMed databases, according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Five papers met the inclusion criteria. Results from two studies of cognitive training and one study of modafinil indicate positive results regarding social cognition outcomes in patients with early psychosis. On the other hand, two studies with oxytocin and modafinil did not suggest such effects. Further research is warranted to explore the benefit of early intervention into disturbances of social cognition in psychoses.
社会认知缺陷是精神分裂症的核心特征，会损害患者的功能。然而，关于精神病早期社会认知障碍治疗效果的证据却很少。在此，我们对早期精神病社会认知障碍及其干预的相关文献进行了系统综述。根据系统评价和Meta分析的首选报告项目（PRISMA）声明的指南，在科学网和PubMed数据库中检索了英文文章。五篇论文符合纳入标准。两项认知训练研究和一项莫达非尼研究的结果表明，早期精神病患者的社会认知结果呈阳性。另一方面，两项关于催产素和莫达非尼的研究并未显示出此类效果。有必要进行进一步的研究，以探索早期干预对精神病患者社会认知障碍的益处。
