Silva Célia, Melnikova Mariia, Ivo Rui Santos, Furtado Cláudia
Information and Strategic Planning Department (DIPE), INFARMED, National Authority of Medicines and Health Products, I.P., Lisbon, Portugal.
, Lisbon, Portugal.
Eur J Pediatr. 2025 Jun 12;184(7):415. doi: 10.1007/s00431-025-06229-y.
This study aims to analyse the prescription of medication for attention-deficit/hyperactivity disorder (ADHD) in children and adolescents, by age group and gender, before and during the COVID-19 pandemic, as well as the impact of government policies during this period. This study was a retrospective cohort analysis using data from the Portuguese national prescription database and included all children and adolescents aged 5-19 years. We conducted an interrupted time series analysis, modelled using a seasonal autoregressive integrated moving average (SARIMA) approach, to evaluate the impact on prescription medications while considering two intervention points resulting from government policies: March 2020, marking the start of strict anti-pandemic measures, and May 2021, marking the beginning of their easing. Following the start of strict anti-pandemic measures, from March 2020 to May 2021, a 9% lower prescription rate than expected was observed, while from June 2021 to December 2023, the prescription rate was greater than expected (+ 32%, with a peak of + 41% in children 5-9 years old) and more pronounced in girls.
These findings highlight the complex impact of the pandemic on different age groups and between genders on the prescription of ADHD medicines.
• ADHD medications are considered effective and have been increasingly prescribed to children and adolescents in recent years.
• Following the COVID-19 pandemic, the increase in ADHD medication prescriptions exceeded expected trends. • Stratification by age group and gender revealed gender differences, with a more pronounced rise in prescriptions observed among girls.
本研究旨在分析新冠疫情之前及期间,按年龄组和性别划分的儿童及青少年注意力缺陷多动障碍(ADHD)药物处方情况,以及这一时期政府政策的影响。本研究是一项回顾性队列分析,使用了葡萄牙国家处方数据库的数据,纳入了所有5至19岁的儿童及青少年。我们采用季节性自回归积分滑动平均(SARIMA)方法进行中断时间序列分析,以评估对处方药的影响,同时考虑政府政策产生的两个干预点:2020年3月,标志着严格抗疫措施的开始;2021年5月,标志着措施开始放宽。在严格抗疫措施开始后,从2020年3月到2021年5月,观察到处方率比预期低9%,而从2021年6月到2023年12月,处方率高于预期(+32%,5至9岁儿童峰值为+41%),且在女孩中更为明显。
这些发现凸显了疫情对不同年龄组以及不同性别ADHD药物处方的复杂影响。
• ADHD药物被认为是有效的,近年来越来越多地开给儿童和青少年。
• 新冠疫情之后,ADHD药物处方的增加超过了预期趋势。• 按年龄组和性别分层显示出性别差异,女孩的处方增加更为明显。