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新冠疫情政策对葡萄牙儿童和青少年多动症药物处方的影响。

Impact of COVID-19 pandemic policies on ADHD medication prescriptions among children and adolescents in Portugal.

作者信息

Silva Célia, Melnikova Mariia, Ivo Rui Santos, Furtado Cláudia

机构信息

Information and Strategic Planning Department (DIPE), INFARMED, National Authority of Medicines and Health Products, I.P., Lisbon, Portugal.

, Lisbon, Portugal.

出版信息

Eur J Pediatr. 2025 Jun 12;184(7):415. doi: 10.1007/s00431-025-06229-y.

Abstract

UNLABELLED

This study aims to analyse the prescription of medication for attention-deficit/hyperactivity disorder (ADHD) in children and adolescents, by age group and gender, before and during the COVID-19 pandemic, as well as the impact of government policies during this period. This study was a retrospective cohort analysis using data from the Portuguese national prescription database and included all children and adolescents aged 5-19 years. We conducted an interrupted time series analysis, modelled using a seasonal autoregressive integrated moving average (SARIMA) approach, to evaluate the impact on prescription medications while considering two intervention points resulting from government policies: March 2020, marking the start of strict anti-pandemic measures, and May 2021, marking the beginning of their easing. Following the start of strict anti-pandemic measures, from March 2020 to May 2021, a 9% lower prescription rate than expected was observed, while from June 2021 to December 2023, the prescription rate was greater than expected (+ 32%, with a peak of + 41% in children 5-9 years old) and more pronounced in girls.

CONCLUSIONS

These findings highlight the complex impact of the pandemic on different age groups and between genders on the prescription of ADHD medicines.

WHAT IS KNOWN

• ADHD medications are considered effective and have been increasingly prescribed to children and adolescents in recent years.

WHAT IS NEW

• Following the COVID-19 pandemic, the increase in ADHD medication prescriptions exceeded expected trends. • Stratification by age group and gender revealed gender differences, with a more pronounced rise in prescriptions observed among girls.

摘要

未标注

本研究旨在分析新冠疫情之前及期间,按年龄组和性别划分的儿童及青少年注意力缺陷多动障碍(ADHD)药物处方情况,以及这一时期政府政策的影响。本研究是一项回顾性队列分析,使用了葡萄牙国家处方数据库的数据,纳入了所有5至19岁的儿童及青少年。我们采用季节性自回归积分滑动平均(SARIMA)方法进行中断时间序列分析,以评估对处方药的影响,同时考虑政府政策产生的两个干预点:2020年3月,标志着严格抗疫措施的开始;2021年5月,标志着措施开始放宽。在严格抗疫措施开始后,从2020年3月到2021年5月,观察到处方率比预期低9%,而从2021年6月到2023年12月,处方率高于预期(+32%,5至9岁儿童峰值为+41%),且在女孩中更为明显。

结论

这些发现凸显了疫情对不同年龄组以及不同性别ADHD药物处方的复杂影响。

已知信息

• ADHD药物被认为是有效的,近年来越来越多地开给儿童和青少年。

新发现

• 新冠疫情之后,ADHD药物处方的增加超过了预期趋势。• 按年龄组和性别分层显示出性别差异,女孩的处方增加更为明显。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae37/12158850/44d9ba604933/431_2025_6229_Fig1_HTML.jpg

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