• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

肠道-脑轴中与代谢调节激素相关的中枢信号通路：综述

The central signaling pathways related to metabolism-regulating hormones of the gut-brain axis: a review.

作者信息

Liu Jiyuan, Jing Changqing, Guo Ying, Shang Zhou, Zhang Baolin, Zhou Xinxiu, Zhang Jizhun, Lian Guodong, Tian Feng, Li Leping, Chen Yuezhi

机构信息

Department of Gastrointestinal Surgery, Shandong Provincial Hospital, Shandong First Medical University, Jinan, 250021, Shandong, China.

Department of General Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.

出版信息

J Transl Med. 2025 Jun 11;23(1):648. doi: 10.1186/s12967-025-06656-3.

DOI:10.1186/s12967-025-06656-3
PMID:40500780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12160472/
Abstract

Obesity is a widespread metabolic disorder linked to various conditions, including type 2 diabetes, hypertension, fatty liver disease, sleep apnea, and hyperuricemia. It significantly impacts quality of life and economic productivity. Traditional methods like diet and lifestyle changes often fail to produce substantial weight loss. Consequently, emerging treatments such as anti-obesity medications, bariatric surgery, and fecal microbiota transplantation are becoming more prominent. Recent research emphasizes the role of hormones that communicate with the hypothalamus through the gut-brain axis, affecting appetite, insulin secretion, and body weight via specific signaling pathways. This review explores the role of key gastrointestinal hormones (GLP-1, PYY, ghrelin, CCK, GIP, leptin, and bile acids) and their signaling pathways in metabolic regulation. The present research systematically evaluates the impact of bariatric surgery on appetite modulation and certain metabolic functions through key signaling pathways, including GLP-1R, GHS-R1a, and FXR/TGR5.

摘要

肥胖是一种广泛存在的代谢紊乱疾病，与多种病症相关，包括2型糖尿病、高血压、脂肪肝疾病、睡眠呼吸暂停和高尿酸血症。它对生活质量和经济生产力有重大影响。诸如饮食和生活方式改变等传统方法往往无法实现显著的体重减轻。因此，抗肥胖药物、减肥手术和粪便微生物群移植等新兴治疗方法正变得越来越突出。最近的研究强调了通过肠脑轴与下丘脑进行沟通的激素的作用，这些激素通过特定的信号通路影响食欲、胰岛素分泌和体重。本综述探讨了关键胃肠激素（胰高血糖素样肽-1、肽YY、胃饥饿素、胆囊收缩素、葡萄糖依赖性促胰岛素多肽、瘦素和胆汁酸）及其信号通路在代谢调节中的作用。本研究通过关键信号通路，包括胰高血糖素样肽-1受体、生长激素促分泌素受体1a和法尼醇X受体/ TGR5，系统地评估了减肥手术对食欲调节和某些代谢功能的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/79945a501d70/12967_2025_6656_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/226f26677fc7/12967_2025_6656_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/39ca20982958/12967_2025_6656_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/f9324e951aec/12967_2025_6656_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/4879ab4102cb/12967_2025_6656_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/3c7e28062f2c/12967_2025_6656_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/baa28c94c1cd/12967_2025_6656_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/396bc87ef108/12967_2025_6656_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/1a3e1ed52440/12967_2025_6656_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/79945a501d70/12967_2025_6656_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/226f26677fc7/12967_2025_6656_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/39ca20982958/12967_2025_6656_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/f9324e951aec/12967_2025_6656_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/4879ab4102cb/12967_2025_6656_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/3c7e28062f2c/12967_2025_6656_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/baa28c94c1cd/12967_2025_6656_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/396bc87ef108/12967_2025_6656_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/1a3e1ed52440/12967_2025_6656_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e704/12160472/79945a501d70/12967_2025_6656_Fig9_HTML.jpg

相似文献

1
The central signaling pathways related to metabolism-regulating hormones of the gut-brain axis: a review.肠道-脑轴中与代谢调节激素相关的中枢信号通路：综述
J Transl Med. 2025 Jun 11;23(1):648. doi: 10.1186/s12967-025-06656-3.
2
Neurohormonal Changes in the Gut-Brain Axis and Underlying Neuroendocrine Mechanisms following Bariatric Surgery.减肥手术后肠道-脑轴的神经激素变化及潜在神经内分泌机制
Int J Mol Sci. 2022 Mar 19;23(6):3339. doi: 10.3390/ijms23063339.
3
Hormonal Gut-Brain Signaling for the Treatment of Obesity.激素肠道-大脑信号在肥胖治疗中的作用。
Int J Mol Sci. 2023 Feb 8;24(4):3384. doi: 10.3390/ijms24043384.
4
Gut-brain mechanisms underlying changes in disordered eating behaviour after bariatric surgery: a review.减重手术后饮食失调行为改变的肠道-大脑机制：综述。
Rev Endocr Metab Disord. 2022 Aug;23(4):733-751. doi: 10.1007/s11154-021-09696-4. Epub 2021 Dec 1.
5
Influence of Bariatric Surgery on Gut Microbiota Composition and Its Implication on Brain and Peripheral Targets.减重手术对肠道微生物组成的影响及其对脑和外周靶标的影响。
Nutrients. 2024 Apr 5;16(7):1071. doi: 10.3390/nu16071071.
6
Obesity, gut hormones, and bariatric surgery.肥胖、肠道激素与减肥手术
World J Surg. 2009 Oct;33(10):1983-8. doi: 10.1007/s00268-009-0080-9.
7
The gut-brain axis: Identifying new therapeutic approaches for type 2 diabetes, obesity, and related disorders.肠脑轴：寻找 2 型糖尿病、肥胖症及相关疾病的新治疗方法。
Mol Metab. 2021 Apr;46:101175. doi: 10.1016/j.molmet.2021.101175. Epub 2021 Feb 3.
8
Multi-omics insights into the microbiota-gut-brain axis and cognitive improvement post-bariatric surgery.多组学解析微生物群-肠-脑轴与减重手术后认知改善的关系
J Transl Med. 2024 Oct 17;22(1):945. doi: 10.1186/s12967-024-05757-9.
9
Obesity: Lifestyle management, bariatric surgery, drugs, and the therapeutic exploitation of gut hormones.肥胖症：生活方式管理、减肥手术、药物以及肠道激素的治疗性应用。
Postgrad Med. 2015 Jun;127(5):494-502. doi: 10.1080/00325481.2015.1048181.
10
Glucagon-Like Peptide 1 Receptor () Deficiency Does Not Appreciably Alter Airway Inflammation or Gut-Lung Microbiome Axis in a Mouse Model of Obese Allergic Airways Disease and Bariatric Surgery.胰高血糖素样肽1受体（）缺乏在肥胖变应性气道疾病和减肥手术小鼠模型中不会明显改变气道炎症或肠-肺微生物群轴。
J Asthma Allergy. 2025 Feb 27;18:285-305. doi: 10.2147/JAA.S478329. eCollection 2025.

本文引用的文献

1
Glucose-dependent insulinotropic polypeptide (GIP).葡萄糖依赖性促胰岛素多肽（GIP）。
Mol Metab. 2025 May;95:102118. doi: 10.1016/j.molmet.2025.102118. Epub 2025 Feb 28.
2
The association between BMI and postoperative pulmonary complications in adults undergoing non-cardiac, non-obstetric surgery: a retrospective cohort study.体重指数与接受非心脏、非产科手术的成人术后肺部并发症之间的关联：一项回顾性队列研究。
Anaesthesia. 2025 Feb 18. doi: 10.1111/anae.16573.
3
Changes in serum ghrelin and resistin levels after sleeve gastrectomy versus one anastomosis gastric bypass: prospective cohort study.
袖状胃切除术与单吻合口胃旁路术后血清 ghrelin 和 resistin 水平的变化：前瞻性队列研究。
Int J Surg. 2024 Sep 1;110(9):5434-5443. doi: 10.1097/JS9.0000000000001608.
4
Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets.健康与疾病中的胆汁酸代谢及信号传导：分子机制与治疗靶点
Signal Transduct Target Ther. 2024 Apr 26;9(1):97. doi: 10.1038/s41392-024-01811-6.
5
Shedding light on cholecystokinin's role in hippocampal neuroplasticity and memory formation.揭示胆囊收缩素在海马神经可塑性和记忆形成中的作用。
Neurosci Biobehav Rev. 2024 Apr;159:105615. doi: 10.1016/j.neubiorev.2024.105615. Epub 2024 Mar 2.
6
Cholecystokinin (CCK): a neuromodulator with therapeutic potential in Alzheimer's and Parkinson's disease.胆囊收缩素（CCK）：一种具有治疗阿尔茨海默病和帕金森病潜力的神经调质。
Front Neuroendocrinol. 2024 Apr;73:101122. doi: 10.1016/j.yfrne.2024.101122. Epub 2024 Feb 10.
7
The vagus nerve mediates the physiological but not pharmacological effects of PYY on food intake.迷走神经介导 PYY 对摄食的生理作用而非药理学作用。
Mol Metab. 2024 Mar;81:101895. doi: 10.1016/j.molmet.2024.101895. Epub 2024 Feb 8.
8
Gut peptides before and following Roux-En-Y gastric bypass: A systematic review and meta-analysis.胃旁路术前和术后的肠肽：系统评价和荟萃分析。
Obes Rev. 2024 May;25(5):e13702. doi: 10.1111/obr.13702. Epub 2024 Feb 7.
9
Mechanism of action of the bile acid receptor TGR5 in obesity.胆汁酸受体TGR5在肥胖中的作用机制。
Acta Pharm Sin B. 2024 Feb;14(2):468-491. doi: 10.1016/j.apsb.2023.11.011. Epub 2023 Nov 10.
10
Obesity Management in Adults: A Review.成人肥胖管理：综述。
JAMA. 2023 Nov 28;330(20):2000-2015. doi: 10.1001/jama.2023.19897.