Behary Preeshila, Cegla Jaimini, Tan Tricia M, Bloom Stephen R
Division of Diabetes, Endocrinology and Metabolism, Hammersmith Hospital, Imperial College London , Du Cane Road, London , UK.
Postgrad Med. 2015 Jun;127(5):494-502. doi: 10.1080/00325481.2015.1048181.
Obesity is on the rise and the pursuit of efficient and safe treatment is ongoing. Available anti-obesity medical therapies have so far proved to be disappointing, whereas bariatric surgery is leading the way and offers long-term health benefits. Part of the success of bariatric surgery is thought to be mediated by gut hormones. A better understanding of the role of gut hormones within the gut-brain signaling pathway in the control of hunger, satiety, and energy homeostasis, has led to their therapeutic exploitation as possible anti-obesity drugs. In this review, we provide a summary of currently available treatment options for obesity from simple lifestyle modifications and bariatric surgery to traditional and novel medical therapies.
肥胖率正在上升，人们仍在不断寻求高效且安全的治疗方法。到目前为止，现有的抗肥胖药物疗法都令人失望，而减肥手术却引领潮流并带来长期健康益处。减肥手术的部分成功被认为是由肠道激素介导的。对肠道激素在肠道-大脑信号通路中控制饥饿、饱腹感和能量平衡方面作用的更好理解，促使人们将其作为可能的抗肥胖药物进行治疗性开发。在本综述中，我们总结了目前可用的肥胖治疗方案，从简单的生活方式改变、减肥手术到传统和新型药物疗法。
