Abulipizi Gulizhabaier, Zhou Juanjuan, Qu Chaomin, Ding Leping, Zong Ziang, Fang Yanlun, Yu Zimin, Shi Xingyuan, Yang Fanwen, Li Zhanjun
Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, Guangdong 511436, P. R. China.
School of Health, Guangzhou Vocational University of Science and Technology, Guangzhou, Guangdong 510080, P. R. China.
ACS Appl Mater Interfaces. 2025 Jun 25;17(25):36912-36921. doi: 10.1021/acsami.5c07800. Epub 2025 Jun 12.
Lanthanide-doped materials were developed with interesting near-infrared (NIR) persistent luminescence (PersL) properties after X-ray irradiation but are limited by poor charging ability based upon biocompatible red light. In this study, CaTiO:Tm (CTT) was found to emit an unusual single band PersL at 800 nm, which was rechargeable by red-NIR light excitation (∼650 to 720 nm). Moreover, blue or deep red light could charge more intense PersL than UV light in CTT, which was quite different from all the other known lanthanide-activated NIR PersL materials. An upconverting-energy transfer PersL mechanism was proposed based on the upconverting property of Tm and its energy transfer to Ti in the CaTiO matrix. The interaction of Tm and Ti in CaTiO quite possibly played an important role in the unusual PersL process of CTT, which avoided the band-pass transition of the CaTiO matrix. By comparison with a series of Tm-doped phosphors, CaTiO was found to be an optimal PersL matrix to generate the unique PersL properties of Tm. The charged NIR PersL imaging of a medical stent implant in the neck of a chicken model was demonstrated. This study reveals the unusual PersL properties of CTT and will promote advanced biomedical applications of rare-earth-doped PersL biomaterials.
镧系元素掺杂材料在X射线辐照后展现出有趣的近红外（NIR）持续发光（PersL）特性，但基于生物相容性红光的充电能力较差，限制了其应用。在本研究中，发现CaTiO:Tm（CTT）在800 nm处发射出异常的单波段持续发光，可通过红-近红外光激发（~650至720 nm）进行充电。此外，在CTT中，蓝光或深红色光比紫外光能使持续发光更强，这与所有其他已知的镧系元素激活的近红外持续发光材料有很大不同。基于Tm的上转换特性及其在CaTiO基质中向Ti的能量转移，提出了一种上转换能量转移持续发光机制。CaTiO中Tm和Ti的相互作用很可能在CTT异常的持续发光过程中起重要作用，避免了CaTiO基质的带通跃迁。通过与一系列Tm掺杂的磷光体比较，发现CaTiO是产生Tm独特持续发光特性的最佳持续发光基质。展示了鸡模型颈部植入的医用支架的带电近红外持续发光成像。本研究揭示了CTT异常的持续发光特性，并将推动稀土掺杂持续发光生物材料在先进生物医学领域的应用。
