Steffen C, Smolen J, Miehlke K, Hörger I, Menzel J
Z Rheumatol. 1985 Mar-Apr;44(2):51-6.
42 patients with definite or classic rheumatoid arthritis were treated with an enzyme mixture (Wobenzym) for 6 weeks. Circulating immune complexes were investigated with a Clq-solid phase RIA in weekly intervals and also rheumatoid factors were determined together with other routine laboratory tests. The condition of patients after therapy was recorded together with amount of circulating immune complexes during treatment. 26 (61.9%) patients improved, 13 (30.9%) patients remained unchanged, and 3 (17.1%) showed impairment. No side effects were observed. Patients who primarily showed no immune complexes or patients who had immune complexes which became negative during enzyme therapy, showed improvement more often than patients which had immune complexes and remained positive during the entire course of therapy.
42例确诊或典型类风湿关节炎患者接受酶混合物（沃布宗）治疗6周。每周用Clq固相放射免疫分析法检测循环免疫复合物，并与类风湿因子及其他常规实验室检查一起测定。记录治疗后患者的状况以及治疗期间循环免疫复合物的数量。26例（61.9%）患者病情改善，13例（30.9%）患者病情无变化，3例（17.1%）患者病情恶化。未观察到副作用。与在整个治疗过程中始终有免疫复合物且呈阳性的患者相比，最初无免疫复合物或在酶治疗期间免疫复合物转阴的患者病情改善更为常见。
