Burns William, Strawderman Emma, Meyers Steven P, Schmidt Tyler, Walter Kevin A, Pilcher Webster H, Mahon Bradford Z, Garcea Frank E
Department of Neurosurgery, University of Rochester Medical Center, USA.
Department of Neuroscience, University of Rochester Medical Center, USA.
bioRxiv. 2025 Jun 6:2025.06.05.658124. doi: 10.1101/2025.06.05.658124.
Speech production is supported by sensory-to-motor transformations to coordinate activity of the larynx and orofacial muscles. Here, we show that lesions to left temporal lobe areas involved in pitch processing cause reduced neural responses when repeating sentences and when humming piano melodies in a dorsal portion of the left precentral gyrus linked to laryngeal motor control. In contrast, lesions to left inferior parietal areas involved in somatosensory processing of speech cause reduced neural responses when repeating sentences but not when humming piano melodies in a ventral portion of the left precentral gyrus linked to orofacial motor control. Analyses in neurotypical participants converge in showing that the dorsal and ventral portions of the left precentral gyrus exhibit strong functional connectivity to left temporal and inferior parietal regions, respectively. These results provide causal lesion evidence that dissociable networks underlie distinct sensory-to-motor transformations supporting laryngeal and orofacial motor control for speech production.
言语产生由感觉运动转换来支持，以协调喉部和口面部肌肉的活动。在此，我们表明，当在与喉部运动控制相关的左侧中央前回背侧部分重复句子和哼唱钢琴旋律时，参与音高处理的左侧颞叶区域受损会导致神经反应减少。相比之下，当在与口面部运动控制相关的左侧中央前回腹侧部分重复句子时，参与言语体感处理的左侧顶下区域受损会导致神经反应减少，但哼唱钢琴旋律时则不会。对神经典型参与者的分析一致表明，左侧中央前回的背侧和腹侧部分分别与左侧颞叶和顶下区域表现出强功能连接。这些结果提供了因果性损伤证据，表明可分离的神经网络是支持言语产生中喉部和口面部运动控制的不同感觉运动转换的基础。
