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强光对……的影响

The effects of intense light on .

作者信息

Kniazeva Marina, Ruvkun Gary

机构信息

Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 and Department of Genetics, Harvard Medical School, Boston, MA 02114.

出版信息

bioRxiv. 2025 Jun 6:2025.06.05.658132. doi: 10.1101/2025.06.05.658132.

Abstract

utilize light receptors to modify foraging and locomotion in response to phototoxic blue and UV light. Our study investigated physiological and behavioral changes in during and after exposure to high-intensity light-emitting diode (LED) light. Our findings corroborate previously reported blue-light-induced oxidative stress, mitochondrial damage, and avoidance behavior. Novel to our work is the identification of a protective role for lysosome-related organelles (LROs), the observation of a unique "shelter-seeking behavior" potentially mediated by light gradient sensing, and the seemingly dispensable role of canonical light receptors in this specific behavioral response.

摘要

利用光感受器来改变觅食和运动,以应对光毒性蓝光和紫外线。我们的研究调查了暴露于高强度发光二极管(LED)光期间及之后的生理和行为变化。我们的发现证实了先前报道的蓝光诱导的氧化应激、线粒体损伤和回避行为。我们工作的新颖之处在于鉴定了溶酶体相关细胞器(LRO)的保护作用,观察到一种可能由光梯度感知介导的独特“寻求庇护行为”,以及经典光感受器在这种特定行为反应中看似可有可无的作用。

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