Kniazeva Marina, Ruvkun Gary
Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 and Department of Genetics, Harvard Medical School, Boston, MA 02114.
bioRxiv. 2025 Jun 6:2025.06.05.658132. doi: 10.1101/2025.06.05.658132.
utilize light receptors to modify foraging and locomotion in response to phototoxic blue and UV light. Our study investigated physiological and behavioral changes in during and after exposure to high-intensity light-emitting diode (LED) light. Our findings corroborate previously reported blue-light-induced oxidative stress, mitochondrial damage, and avoidance behavior. Novel to our work is the identification of a protective role for lysosome-related organelles (LROs), the observation of a unique "shelter-seeking behavior" potentially mediated by light gradient sensing, and the seemingly dispensable role of canonical light receptors in this specific behavioral response.
利用光感受器来改变觅食和运动，以应对光毒性蓝光和紫外线。我们的研究调查了暴露于高强度发光二极管（LED）光期间及之后的生理和行为变化。我们的发现证实了先前报道的蓝光诱导的氧化应激、线粒体损伤和回避行为。我们工作的新颖之处在于鉴定了溶酶体相关细胞器（LRO）的保护作用，观察到一种可能由光梯度感知介导的独特“寻求庇护行为”，以及经典光感受器在这种特定行为反应中看似可有可无的作用。
