Emami Asrin, Kalantar Seyed Hadi, Mafhumi Asma, Saffar Hiva, Oskouie Iman Menbari
Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Joint Reconstruction Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Adv Orthop. 2025 Jun 4;2025:7262524. doi: 10.1155/aort/7262524. eCollection 2025.
Bone fractures involving critical-sized defects pose a significant challenge in orthopedic surgery, often requiring innovative strategies to promote bone regeneration. This study aimed to evaluate the effectiveness of polypropylene surgical mesh in repairing critical-sized radius bone defects in a rat model. Treatments included autologous grafts and a combination of mesh and graft, compared with an untreated control group. After 6 weeks, X-ray and CT scan analyses revealed significant bone healing and callus formation in the treated groups, with the graft + mesh group showing the most pronounced improvement. Histomorphometric analyses demonstrated that the mesh scaffold significantly enhanced new bone formation, osteoblast and osteocyte counts, and bone microarchitecture compared with grafts alone. These findings suggest that mesh scaffolds offer superior osteogenic potential and could provide a promising adjunct for treating critical-sized bone defects. Future studies should explore optimized mesh designs and the interplay between osteogenesis and angiogenesis to improve clinical outcomes.
涉及临界尺寸缺损的骨折在骨科手术中构成重大挑战，通常需要创新策略来促进骨再生。本研究旨在评估聚丙烯外科网片在大鼠模型中修复临界尺寸桡骨缺损的有效性。治疗方法包括自体移植以及网片与移植相结合，与未治疗的对照组进行比较。6周后，X射线和CT扫描分析显示治疗组有显著的骨愈合和骨痂形成，移植+网片组改善最为明显。组织形态计量学分析表明，与单独移植相比，网片支架显著增强了新骨形成、成骨细胞和骨细胞数量以及骨微结构。这些发现表明，网片支架具有卓越的成骨潜力，可为治疗临界尺寸骨缺损提供有前景的辅助手段。未来的研究应探索优化的网片设计以及成骨与血管生成之间的相互作用，以改善临床结果。
