Wachamo Samuel, Gaultier Alban
Department of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA.
Brain Behav Immun Health. 2025 May 7;46:101012. doi: 10.1016/j.bbih.2025.101012. eCollection 2025 Jul.
The microbiota-gut-brain axis (MGBA), the bidirectional communication network between the gastrointestinal tract and the central nervous system, plays a significant role in the pathophysiology of neurodegenerative disorders. Emerging research highlights how gut microbiota dysbiosis, or an imbalance in the microbial community, is linked to the etiology and pathology of these conditions. Microbiota dysbiosis leads to changes in the production of microbial metabolites, such as short-chain fatty acids (SCFAs), which can cross the intestinal barrier and influence the brain either directly or indirectly. Understanding the mechanisms by which dysfunction in the MGBA contributes to neurodegeneration opens potential avenues for novel therapeutic strategies, including microbiota-targeted interventions. This review introduces the MGBA, discusses the role of SCFAs within the MGBA in the context of neurodegenerative disorders, and suggests future research directions.
微生物群-肠-脑轴（MGBA）是胃肠道与中枢神经系统之间的双向通信网络，在神经退行性疾病的病理生理学中起着重要作用。新兴研究突出了肠道微生物群失调，即微生物群落失衡，如何与这些疾病的病因和病理相关联。微生物群失调会导致微生物代谢产物的产生发生变化，如短链脂肪酸（SCFAs），它们可以穿过肠道屏障，直接或间接地影响大脑。了解MGBA功能障碍导致神经退行性变的机制为新的治疗策略开辟了潜在途径，包括针对微生物群的干预措施。本综述介绍了MGBA，讨论了在神经退行性疾病背景下SCFAs在MGBA中的作用，并提出了未来的研究方向。
