Tamargo Javier A, Cruz-Almeida Yenisel
University of Florida.
Res Sq. 2025 May 28:rs.3.rs-6733184. doi: 10.21203/rs.3.rs-6733184/v1.
Chronic pain epidemiology is hindered by inconsistent definitions and methods. The U.S. National Pain Strategy introduced high-impact chronic pain as a pain surveillance standard, defined as chronic pain that interferes with daily life. This study aimed to validate the operationalization of high-impact pain in the Health and Retirement Study (HRS), a large, nationally representative cohort of older adults.
We analyzed data from the 2010 HRS pain module. High-impact pain was operationalized with two questions that have been fielded in the HRS nearly since its inception. Pain intensity and pain-related disability were assessed using numeric rating scales and the Pain Disability Index (PDI). We used Wilcoxon rank-sum tests and logistic regressions to compare high- versus low-impact pain. Pain impact was also assessed at a 2-year follow-up in 2012.
Out of 508 participants, 335 (65.9%) reported high-impact pain. Those with high-impact pain had significantly higher pain-related disability (median PDI: 48 [33, 60] vs. 19 [8, 36], P<0.0001), average pain intensity (median: 6 [4, 8] vs. 5 [3, 6], P<0.0001) and were more likely to report chronic (OR: 1.75 [95% CI: 0.19, 2.58]) and constant (OR: 3.09 [1.93, 4.93]) pain. High-impact pain was associated with a relative risk of 1.80 (1.53, 2.11) for continued high-impact pain at a 2-year follow-up.
The HRS operationalization of high-impact pain demonstrates strong concurrent validity with established measures of pain disability, intensity, and impact. The HRS provides a valuable tool for advancing pain research, particularly in aging populations.
慢性疼痛流行病学因定义和方法不一致而受到阻碍。美国国家疼痛战略引入了高影响性慢性疼痛作为疼痛监测标准,定义为干扰日常生活的慢性疼痛。本研究旨在验证健康与退休研究(HRS)中高影响性疼痛的操作化定义,HRS是一个具有全国代表性的老年人群大样本队列。
我们分析了2010年HRS疼痛模块的数据。高影响性疼痛通过自HRS开展以来几乎一直在使用的两个问题进行操作化定义。使用数字评分量表和疼痛残疾指数(PDI)评估疼痛强度和与疼痛相关的残疾情况。我们使用Wilcoxon秩和检验和逻辑回归来比较高影响性疼痛与低影响性疼痛。2012年还对疼痛影响进行了为期2年的随访评估。
在508名参与者中,335名(65.9%)报告有高影响性疼痛。有高影响性疼痛的参与者与疼痛相关的残疾程度显著更高(PDI中位数:48[33,60]对19[8,36],P<0.0001),平均疼痛强度更高(中位数:6[4,8]对5[3,6],P<0.0001),并且更有可能报告慢性疼痛(比值比:1.75[95%置信区间:0.19,2.58])和持续性疼痛(比值比:3.09[1.93,4.93])。在2年随访中,高影响性疼痛与持续高影响性疼痛的相对风险为1.80(1.53,2.11)。
HRS对高影响性疼痛的操作化定义与已确立的疼痛残疾、强度和影响测量方法具有很强的同时效度。HRS为推进疼痛研究提供了一个有价值的工具,特别是在老年人群中。