Malhotra Amisha, Rao Gayathri M, Marathe Aradhana, Jothi Sowmya Ananda, Chandran Vinod
Department of Biochemistry, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India.
J Circ Biomark. 2025 Jun 9;14:1-4. doi: 10.33393/jcb.2025.3396. eCollection 2025 Jan-Dec.
This research was performed to evaluate Irisin and Insulin concentrations in Thyroid patients.
This investigation was performed as a cross-sectional study within the Biochemistry Department at KMC, Mangalore, and the Central Lab at KMCH-AT, Mangalore. Participants were classified into two cohorts: those having regular thyroid function as well as those having thyroid disorder, including both hypothyroid and hyperthyroid patients, with 28 individuals (n = 28) in each category based on thyroid stimulating hormone (TSH) levels obtained during thyroid dysfunction screenings. Socio-demographic variables like height, weight, and body mass index were calculated, along with the assessment of hypertensive or hypotensive conditions. Insulin levels were quantified using an automated analyzer system. Statistical analyses were performed utilizing Easy-R (EZR) version 1.55, developed by Jichi Medical University in Saitama, Japan. The normal distribution of the parameters was evaluated through normality tests, with t-tests and Kruskal-Wallis tests applied as appropriate.
Irisin levels significantly declined in hypothyroid individuals while showing an insignificant rise in hyperthyroidism. Insulin levels significantly increased in hyperthyroid patients compared to normal and hypothyroid groups. A positive correlation between insulin and irisin was found in hypothyroidism, while a negative correlation was observed in hyperthyroidism.
Preliminary findings of this study indicate a potential interdependence between Irisin and thyroid levels. Investigating the interaction between the thyroid profile and irisin can pave the way for considering irisin as a biomarker for novel treatment strategies in thyroid disorders and metabolic conditions.
本研究旨在评估甲状腺疾病患者中鸢尾素和胰岛素的浓度。
本调查作为一项横断面研究，在芒格洛尔卡纳塔克医学中心生物化学系以及芒格洛尔KMCH-AT中央实验室进行。参与者被分为两组：甲状腺功能正常者以及患有甲状腺疾病者，包括甲状腺功能减退和甲状腺功能亢进患者，根据甲状腺功能障碍筛查期间获得的促甲状腺激素（TSH）水平，每组各有28人（n = 28）。计算身高、体重和体重指数等社会人口统计学变量，并评估高血压或低血压情况。使用自动分析仪系统对胰岛素水平进行定量。利用日本埼玉县慈惠会医科大学开发的Easy-R（EZR）版本1.55进行统计分析。通过正态性检验评估参数的正态分布，并酌情应用t检验和Kruskal-Wallis检验。
甲状腺功能减退个体的鸢尾素水平显著下降，而甲状腺功能亢进时鸢尾素水平升高不显著。与正常组和甲状腺功能减退组相比，甲状腺功能亢进患者的胰岛素水平显著升高。甲状腺功能减退时胰岛素与鸢尾素呈正相关，而甲状腺功能亢进时呈负相关。
本研究的初步结果表明鸢尾素与甲状腺水平之间可能存在相互依存关系。研究甲状腺状况与鸢尾素之间的相互作用可为将鸢尾素作为甲状腺疾病和代谢状况新治疗策略的生物标志物提供思路。
