Şahin Mustafa, Canpolat Asena Gökçay, Çorapçioğlu Demet, Canpolat Uğur, Emral Rıfat, Uysal Ali Rıza
a Department of Endocrinology and Metabolism , Ankara University Faculty of Medicine , Ankara , Turkey.
b Department of Cardiology , Hacettepe University Faculty of Medicine , Ankara , Turkey.
Biomarkers. 2018 Dec;23(8):742-747. doi: 10.1080/1354750X.2018.1485056. Epub 2018 Jul 25.
Hyperthyroidism is associated with increased metabolic activity and thermogenesis. Irisin is a key molecule in thermogenesis and energy expenditure via adipose tissue browning. Epicardial fat was previously defined as brown-like fat. Thus, here we aimed to evaluate the association between serum irisin level and epicardial fat thickness (EFT) in patients with hyperthyroidism.
A total of 25 hyperthyroid patients and 24 age-, sex- and BMI-matched healthy controls were enrolled. Serum irisin levels, thyroid hormone levels, and body compositions were compared. EFT was measured via transthoracic echocardiography.
Serum irisin level and EFT were significantly higher in the hyperthyroid group (p < 0.001 and p = 0.001, respectively). The distributions of fat-free mass, muscle mass and fat mass were similar between the study groups. Serum irisin level was negatively correlated with TSH (p < 0.001) and positively correlated with fT3 (p < 0.001), fT4 (p < 0.001) and TSH receptor antibody (p = 0.002) levels and EFT (p = 0.001). In multivariate linear regression analysis, TSH (β = -0.475, p < 0.001) and EFT (β = 0.290, p = 0.023) levels were significantly associated with serum irisin levels.
An increased serum irisin level associated with EFT might contribute to metabolic derangement in hyperthyroidism. Further studies are needed to elucidate whether irisin levels and EFT are affected by hyperthyroidism or vice versa.
甲状腺功能亢进与代谢活动增加和产热有关。鸢尾素是通过脂肪组织褐变实现产热和能量消耗的关键分子。心外膜脂肪以前被定义为类棕色脂肪。因此，我们旨在评估甲状腺功能亢进患者血清鸢尾素水平与心外膜脂肪厚度（EFT）之间的关联。
共纳入25例甲状腺功能亢进患者和24例年龄、性别和体重指数相匹配的健康对照者。比较血清鸢尾素水平、甲状腺激素水平和身体成分。通过经胸超声心动图测量EFT。
甲状腺功能亢进组的血清鸢尾素水平和EFT显著更高（分别为p < 0.001和p = 0.001）。研究组之间的去脂体重、肌肉量和脂肪量分布相似。血清鸢尾素水平与促甲状腺激素（TSH）呈负相关（p < 0.001），与游离三碘甲状腺原氨酸（fT3）（p < 0.001）、游离甲状腺素（fT4）（p < 0.001）和促甲状腺激素受体抗体（p = 0.002）水平以及EFT（p = 0.001）呈正相关。在多变量线性回归分析中，TSH（β = -0.475，p < 0.001）和EFT（β = 0.290，p = 0.023）水平与血清鸢尾素水平显著相关。
与EFT相关的血清鸢尾素水平升高可能导致甲状腺功能亢进患者的代谢紊乱。需要进一步研究以阐明鸢尾素水平和EFT是受甲状腺功能亢进影响还是反之亦然。
