Wen Rui-Ming, Wang Hai-Xia
School of Sports Health, Shenyang Sport University, Shenyang 110102, Liaoning Province, China.
College of Exercise and Health, Shenyang Sport University, Shenyang 110102, Liaoning Province, China.
World J Stem Cells. 2025 May 26;17(5):106150. doi: 10.4252/wjsc.v17.i5.106150.
During excessive adipose tissue accumulation, various adipokines such as visfatin, chemerin, vaspin, and adiponectin are released into systemic circulation, thereby influencing metabolic tissue function throughout the body. As multifunctional signaling molecules secreted by adipose tissue, adipokines play a pivotal role in metabolic regulation, inflammatory response, and tissue homeostasis. Recent studies have demonstrated that adipokines can influence skeletal system repair and regeneration by modulating bone marrow-derived mesenchymal stem cell (BMSC) proliferation, differentiation, migration, and immunomodulatory functions. However, different adipokines have distinct roles in regulating BMSC function, but their underlying molecular mechanisms are not fully understood. In this review, we systematically summarize the specific mechanisms of action and potential clinical applications of visfatin, chemerin, vaspin, and adiponectin on BMSC function in order to reveal new mechanisms of interaction between adipokines and BMSCs. The aim is to provide a theoretical basis for targeted treatment strategies for bone diseases targeting adipokines.
在脂肪组织过度蓄积期间，多种脂肪因子如内脂素、趋化素、内脏脂肪素和脂联素被释放到体循环中，从而影响全身的代谢组织功能。作为脂肪组织分泌的多功能信号分子，脂肪因子在代谢调节、炎症反应和组织稳态中起关键作用。最近的研究表明，脂肪因子可通过调节骨髓间充质干细胞（BMSC）的增殖、分化、迁移和免疫调节功能来影响骨骼系统的修复和再生。然而，不同的脂肪因子在调节BMSC功能方面具有不同的作用，但其潜在的分子机制尚未完全阐明。在本综述中，我们系统地总结了内脂素、趋化素、内脏脂肪素和脂联素对BMSC功能的具体作用机制和潜在临床应用，以揭示脂肪因子与BMSC之间相互作用的新机制。目的是为针对脂肪因子的骨疾病靶向治疗策略提供理论依据。
