Division of Endocrinology and Metabolism, First Department of Internal Medicine, Medical School, AHEPA University Hospital, Aristotle University of Thessaloniki, 1 St. Kiriakidi Street, 54636 Thessaloniki, Greece.
Second Propaedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration General Hospital, 54642 Thessaloniki, Greece.
Nutrients. 2023 Dec 9;15(24):5058. doi: 10.3390/nu15245058.
Athonian Orthodox fasting (AOF) is characterized by energy- and time-restricted eating (TRE) and is based on the Mediterranean diet. We aimed to investigate the impact of AOF compared to another TRE model on vaspin, omentin, nesfatin, and visfatin levels. We included 25 individuals (mean age 50.3 ± 8.6 years, 24% men) who practiced AOF and abstained from animal products, with the exception of seafood and fish. This group adopted a 12 h eating interval (08.00 to 20.00). In total, 12 participants (mean age 47.7 ± 8.7 years, 33.3% men) who practiced 16:8 TRE (eating from 09:00 to 17:00) and were allowed to consume meat served as the controls. Anthropometric and dietary data and adipokine levels were prospectively collected at three time points: at baseline, after the end of the diets (7 weeks), and 5 weeks after the participants returned to their typical eating habits (12 weeks from baseline). Vaspin levels decreased [795.8 (422.1-1299.4) (baseline) vs. 402.7 (203.8-818.9) (7 weeks) pg/mL, = 0.002] and omentin levels increased [568.5 (437.7-1196.5) (baseline) vs. 659.0 (555.7-1810.8) (12 weeks) pg/mL, = 0.001] in the AOF group, while none of the analyzed adipokines changed significantly in the TRE group. The variations observed in vaspin and omentin concentrations in the AOF group were independent of age, sex, changes in anthropometry and fat intake. In conclusion, AOF can significantly reduce vaspin and increase omentin, whose levels are known to increase and decrease, respectively, in obesity and type 2 diabetes. The implications of these findings for cardiometabolic health warrant further investigation.
阿特霍恩东正教禁食（AOF）的特点是能量和时间限制进食（TRE），并基于地中海饮食。我们旨在研究与另一种 TRE 模型相比，AOF 对 vaspin、omentin、nesfatin 和 visfatin 水平的影响。我们纳入了 25 名参与者（平均年龄 50.3±8.6 岁，24%为男性），他们遵循 AOF，除了海鲜和鱼类外，不食用动物产品。该组采用 12 小时进食间隔（08.00 至 20.00）。共有 12 名参与者（平均年龄 47.7±8.7 岁，33.3%为男性）遵循 16:8 TRE（从 09:00 到 17:00 进食），并允许食用肉类，作为对照组。在三个时间点前瞻性收集了人体测量学和饮食数据以及 adipokine 水平：基线时、饮食结束后（7 周）以及参与者恢复典型饮食习惯后 5 周（从基线开始的 12 周）。AOF 组的 vaspin 水平下降[795.8（422.1-1299.4）（基线）比 402.7（203.8-818.9）（7 周）pg/mL， = 0.002]，omentin 水平升高[568.5（437.7-1196.5）（基线）比 659.0（555.7-1810.8）（12 周）pg/mL， = 0.001]，而 TRE 组中没有一种分析的 adipokine 显著变化。AOF 组中 vaspin 和 omentin 浓度的变化与年龄、性别、人体测量和脂肪摄入量的变化无关。总之，AOF 可显著降低 vaspin 并升高 omentin，其水平分别在肥胖和 2 型糖尿病中升高和降低。这些发现对心脏代谢健康的影响值得进一步研究。
