Davanger M, Olsen E G
Acta Ophthalmol (Copenh). 1985 Aug;63(4):443-8. doi: 10.1111/j.1755-3768.1985.tb01561.x.
The interaction of confronting corneal epithelium and endothelium has been studied by cultivation of corneas with open perforating wounds. In some experiments, the epithelium and the endothelium were initially damaged adjacent to the perforation, and the repair capacity was reduced by adding steroids or colchicine to the culture medium. The specimens were examined by scanning electron microscopy. The epithelium covered the stromal walls of the open perforation within 3 days. In most experiments, the epithelium and the endothelium met at the cut edge of Descemet's membrane, and this appeared to be a stable situation. However, if the endothelium was damaged and had reduced repair capacity, the epithelium invaded Descemet's membrane. The clinical implication is that the risk of epithelial ingrowth is present in eyes with a pathological endothelium.
通过对开放性穿孔伤口的角膜进行培养，研究了角膜上皮与内皮的相互作用。在一些实验中，上皮和内皮最初在穿孔附近受损，并且通过向培养基中添加类固醇或秋水仙碱来降低修复能力。通过扫描电子显微镜检查标本。上皮在3天内覆盖了开放性穿孔的基质壁。在大多数实验中，上皮和内皮在Descemet膜的切缘处相遇，这似乎是一种稳定的情况。然而，如果内皮受损且修复能力降低，上皮会侵入Descemet膜。临床意义在于，在内皮病变的眼中存在上皮内生的风险。
