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口服低分子量水解蛋黄肽通过调节骨代谢和免疫反应增加骨密度。

Oral Administration of Hydrolyzed Egg Yolk Peptides With Low Molecular Weight Increased Bone Density by Regulating Bone Metabolism and Immune Responses.

作者信息

Luan Weiying, Hu Yemin, Sun Wei, Bao Jiasheng, Pan Bingzhen, Mai Haimin, Li Qi, He Ruikun, Zhang Xuguang, Jiao Hong

机构信息

School of Food Science and Engineering, South China University of Technology, Guangzhou, China.

BYHEALTH Institute of Nutrition & Health, BYHEALTH Co., Ltd., Guangzhou, China.

出版信息

J Food Sci. 2025 Jun;90(6):e70255. doi: 10.1111/1750-3841.70255.

DOI:10.1111/1750-3841.70255
PMID:40504632
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12161490/
Abstract

Hydrolyzed egg yolk peptides have been proven to improve bone density in animals of different ages. However, the peptides profile and function of low molecular weight hydrolyzed egg yolk peptides have not been studied, which may have better efficacy, the relationship between these peptides and humoral immunity has not been noticed yet. This study analyzed the amino acid composition and molecular weight distribution of Shinupep, a low-molecular-weight hydrolyzed egg yolk peptides suitable for industrial production. It also investigated its effects and mechanisms in improving osteoporosis in ovariectomized rats. Oral administration 8.33 and 50 mg/d/kg Shinupep significantly increased the levels of the bone formation marker BGP while reducing the levels of bone resorption markers alkaline phosphatase and tartrate-resistant acid phosphatase. It also notably enhanced humoral immunity markers immunoglobulin G and immunoglobulin M and lowered the inflammatory marker receptor activator for nuclear factor-κB ligand. Additionally, Shinupep significantly increased cortical bone thickness, trabecular number, and bone density. The improvements in bone density and microarchitecture observed with the Shinupep were achieved through the regulation of bone metabolism, as well as modulation of both humoral and cellular immunity. Notably, this is the first time to reveal the role of humoral immunity in the hydrolyzed egg yolk peptides' ability to ameliorate osteoporosis.

摘要

水解蛋黄肽已被证明可提高不同年龄段动物的骨密度。然而，低分子量水解蛋黄肽的肽谱和功能尚未得到研究，其可能具有更好的功效，且这些肽与体液免疫之间的关系尚未被关注。本研究分析了适用于工业生产的低分子量水解蛋黄肽Shiunpep的氨基酸组成和分子量分布。还研究了其改善去卵巢大鼠骨质疏松症的作用及机制。口服8.33和50mg/d/kg的Shiunpep可显著提高骨形成标志物骨钙素（BGP）的水平，同时降低骨吸收标志物碱性磷酸酶和抗酒石酸酸性磷酸酶的水平。它还显著增强了体液免疫标志物免疫球蛋白G和免疫球蛋白M，并降低了炎症标志物核因子κB受体激活剂配体。此外，Shiunpep显著增加了皮质骨厚度、骨小梁数量和骨密度。观察到Shiunpep对骨密度和微观结构的改善是通过调节骨代谢以及调节体液免疫和细胞免疫实现的。值得注意的是，这是首次揭示体液免疫在水解蛋黄肽改善骨质疏松症能力中的作用。

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本文引用的文献

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Modification Effects of Microorganisms and Enzymes on Egg Components: A Review.微生物和酶对蛋品成分的修饰作用：综述。
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Emulsifying properties of egg proteins: Influencing factors, modification techniques, and applications.蛋清蛋白的乳化性质：影响因素、修饰技术及应用。
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Hydrolyzed egg yolk peptide prevented osteoporosis by regulating Wnt/β-catenin signaling pathway in ovariectomized rats.
水解蛋黄肽通过调节去卵巢大鼠的Wnt/β-连环蛋白信号通路预防骨质疏松症。
Sci Rep. 2024 May 3;14(1):10227. doi: 10.1038/s41598-024-60514-8.
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Orally administrable peptides derived from egg yolk promote skeletal repair and ameliorate degenerative skeletal disorders in mouse models.源自蛋黄的可口服肽可促进小鼠模型中的骨骼修复并改善退行性骨骼疾病。
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Reduction of Mature B Cells and Immunoglobulins Results in Increased Trabecular Bone.成熟B细胞和免疫球蛋白减少导致小梁骨增加。
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