人体唾液中褪黑素的昼夜节律。

Diurnal rhythm of melatonin in human saliva.

作者信息

Vakkuri O

出版信息

Acta Physiol Scand. 1985 Jul;124(3):409-12. doi: 10.1111/j.1748-1716.1985.tb07676.x.

DOI:10.1111/j.1748-1716.1985.tb07676.x

Abstract

Human mixed saliva extracted with chloroform was found to contain immunoreactive melatonin which eluted in HPLC as synthetic melatonin. There was a clear diurnal rhythm in saliva melatonin with low day and high night levels. A similar rhythm was observed in serum. The high night levels in saliva were lower than the corresponding levels in serum. The calculated secretion rate of melatonin into saliva was less than 0.5-0.9 pmol X h-1 during the day and 1.0-2.4 pmol X h-1 during the night. Saliva sampling can be used as a simple and non-invasive way of studying melatonin secretion in human body.

摘要

用氯仿提取的人类混合唾液中发现含有免疫反应性褪黑素，其在高效液相色谱（HPLC）中的洗脱情况与合成褪黑素相同。唾液中褪黑素存在明显的昼夜节律，白天水平低，夜间水平高。血清中也观察到类似的节律。唾液中夜间的高水平低于血清中的相应水平。计算得出，白天褪黑素分泌到唾液中的速率小于0.5 - 0.9皮摩尔×小时⁻¹，夜间为1.0 - 2.4皮摩尔×小时⁻¹。唾液采样可作为一种简单且非侵入性的方法来研究人体褪黑素的分泌。