Laakso M L, Leinonen L, Hätönen T, Alila A, Heiskala H
Department of Physiology, University of Helsinki, Finland.
J Neurol. 1993 Jul;240(7):410-6. doi: 10.1007/BF00867353.
The daily rhythms of melatonin, cortisol and body temperature were studied in 16 institutionalized subjects with the Lennox-Gastaut syndrome. The results of 9 subjects with normal daily rhythms of sleep and wakefulness (group 1) were compared with those of 7 subjects with disordered sleep (group 2). Salivary samples were collected and axillary temperature was measured every 2 h during two or three separate 26-h periods. The hormones were measured by radioimmunoassays. The rhythms were characterized with single cosinor analysis. Two subjects in group 1 and six subjects in group 2 had abnormalities in their rhythms of temperature, cortisol or melatonin. All three rhythms were disrupted in two subjects of group 2. These two subjects were the only ones with disrupted cortisol rhythm. The diversity of rhythm pathologies suggested partly separate regulatory mechanisms for each rhythm. The co-occurrence of circadian rhythm sleep disorders with the deteriorated melatonin rhythm raised the question as to whether the sleep disorders of these subjects, like those of subjects with healthy brains, could be relieved by the induction of normal melatonin rhythm.
对16名患有伦诺克斯 - 加斯东综合征的机构收容患者的褪黑素、皮质醇和体温的每日节律进行了研究。将9名睡眠和觉醒每日节律正常的患者（第1组）的结果与7名睡眠紊乱患者（第2组）的结果进行了比较。在两到三个单独的26小时时间段内，每2小时采集一次唾液样本并测量腋窝温度。通过放射免疫分析法测定激素。通过单余弦分析对节律进行特征描述。第1组中有2名患者，第2组中有6名患者的体温、皮质醇或褪黑素节律存在异常。第2组中的2名患者所有三种节律均被打乱。这两名患者是仅有的皮质醇节律被打乱的患者。节律病理的多样性表明每种节律的调节机制部分独立。昼夜节律性睡眠障碍与褪黑素节律恶化同时出现，这就提出了一个问题，即这些患者的睡眠障碍是否像健康大脑患者的睡眠障碍一样，可以通过诱导正常的褪黑素节律来缓解。
