心绞痛或致命性心肌梗死患者血清磷脂中花生四烯酸的水平。

Arachidonic acid levels in serum phospholipids of patients with angina pectoris or fatal myocardial infarction.

作者信息

Skuladottir G, Hardarson T, Sigfusson N, Oddsson G, Gudbjarnason S

出版信息

Acta Med Scand. 1985;218(1):55-8. doi: 10.1111/j.0954-6820.1985.tb08824.x.

DOI:10.1111/j.0954-6820.1985.tb08824.x

Abstract

The fatty acid composition and concentrations of serum phospholipids (PL) were examined in 14 normal subjects (NS), 10 patients with coronary heart disease (CHD) and stable angina pectoris, and in 12 patients with acute, fatal myocardial infarction (MI). The NS and patients with CHD and stable angina pectoris were matched with respect to age, height, body weight, blood pressure and serum cholesterol. Serum PL of patients with CHD and of patients with acute, fatal MI contained significantly more arachidonic acid (20:4n6, AA) than serum PL of the NS. Docosahexaenoic acid (22:6n3, DHA) was also increased in serum PL of patients with acute, fatal MI. AA and DHA levels in serum PL reflect changes in lipid metabolism that may relate to the cause and/or consequences of CHD.

摘要

对14名正常受试者（NS）、10名患有冠心病（CHD）且心绞痛稳定的患者以及12名急性致命性心肌梗死（MI）患者的血清磷脂（PL）的脂肪酸组成和浓度进行了检测。正常受试者以及患有冠心病且心绞痛稳定的患者在年龄、身高、体重、血压和血清胆固醇方面相匹配。冠心病患者和急性致命性心肌梗死患者的血清PL所含花生四烯酸（20:4n6，AA）明显多于正常受试者的血清PL。二十二碳六烯酸（22:6n3，DHA）在急性致命性心肌梗死患者的血清PL中也有所增加。血清PL中的AA和DHA水平反映了可能与冠心病的病因和/或后果相关的脂质代谢变化。