海风藤（胡椒科胡椒属植物）：植物学、传统用途、植物化学、药理学及质量控制的综合综述
Piper kadsura (Choisy) Ohwi: A comprehensive review of botany, traditional uses, phytochemistry, pharmacology, and quality control.
作者信息
Pan Hao, Wang Changfu, Qin Ying, Zhang Ning, Bian Zhenhua, Chen Tongtong, Liu Yuxin, Lei Xia, Li Xiaoliang
机构信息
Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education & International Joint Research Center of Human-machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province & Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, Hainan, 571199, China.
Guangdong Engineering Technology Research Center for Standardized Processing of Chinese Materia Medica, School of Chinese Materia Medica, Guangdong Pharmaceutical University, China.
出版信息
J Ethnopharmacol. 2025 Jun 10;351:120134. doi: 10.1016/j.jep.2025.120134.
ETHNOPHARMACOLOGICAL RELEVANCE
Piper kadsura (Choisy) Ohwi (P. kadsura), locally known as "Haifengteng", is a traditional East Asian herb with over 2000 years of ethnomedicinal use. It exhibits traditional therapeutic effects, including dispelling rheumatism, dredging meridians, and alleviating arthralgia, and is primarily used to prevent and treat rheumatic diseases.
AIM OF THE STUDY
This paper reviews the research progress on the botany, traditional uses, phytochemistry, pharmacology, and quality control of P. kadsura to provide a scientific basis for its rational utilization and further research.
MATERIALS AND METHODS
The information on P. kadsura was obtained from books related to traditional Chinese medicine and electronic databases, including Web of Science, PubMed, Google Scholar, and CNKI.
RESULTS
P. kadsura has shown significant efficacy in preventing and treating rheumatic diseases when used alone, in herbal formulations, or in traditional Chinese medicated diets. To date, 208 compounds, including phenylpropanoids, alkaloids, terpenoids, steroids, flavonoids, and others, as well as 379 essential oils, have been identified in P. kadsura. Pharmacological studies have confirmed that its extracts and compounds exhibit diverse activities, including anti-platelet activating factor, anti-inflammatory, analgesic, antioxidant, neuroprotective effects against Alzheimer's disease, anticancer, antiviral, and harmful biological control effects.
CONCLUSIONS
P. kadsura exhibits a diverse chemical composition and a wide range of pharmacological activities. Despite recent research progress, there are still some deficiencies, including limited isolation studies of new compounds, incomplete elucidation of some pharmacological mechanisms, significant gaps in pharmacokinetic research, and the need for standardized quality control measures. Future research should address these issues to fully realize its medicinal potential and value.
民族药理学相关性
海风藤（Piper kadsura (Choisy) Ohwi），当地称为“海风藤”，是一种具有2000多年民族药用历史的传统东亚草药。它具有传统治疗功效，包括祛风湿、通经络、止痹痛，主要用于预防和治疗风湿性疾病。
研究目的
本文综述海风藤在植物学、传统用途、植物化学、药理学及质量控制方面的研究进展，为其合理利用和进一步研究提供科学依据。
材料与方法
有关海风藤的信息来自与中医相关的书籍以及电子数据库，包括Web of Science、PubMed、谷歌学术和中国知网。
结果
海风藤单独使用、制成草药配方或用于中医食疗时，在预防和治疗风湿性疾病方面均显示出显著疗效。迄今为止，已从海风藤中鉴定出208种化合物，包括苯丙素类、生物碱、萜类、甾体、黄酮类等，以及379种挥发油。药理学研究证实，其提取物和化合物具有多种活性，包括抗血小板活化因子、抗炎、镇痛、抗氧化、对阿尔茨海默病的神经保护作用、抗癌、抗病毒以及有害生物防治作用。
结论
海风藤具有多样的化学成分和广泛的药理活性。尽管最近有研究进展，但仍存在一些不足，包括新化合物的分离研究有限、部分药理机制阐释不完整、药代动力学研究存在重大差距以及需要标准化质量控制措施。未来的研究应解决这些问题，以充分实现其药用潜力和价值。
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