Gong Li, Ge Qing
Department of Neurology and Endocrinology, Chongqing Jiulongpo People's Hospital, No. 23, Yangjiaping Qianjin Road, Jiulongpo District, Chongqing, 400050, China.
Diabetol Metab Syndr. 2025 Jun 12;17(1):208. doi: 10.1186/s13098-025-01789-3.
The relationship between Klotho, blood glucose levels, and cognitive function is well-established. However, limited data exist on the association between Klotho and cognitive function in diabetes individuals.
To investigate the potential link between serum Klotho levels and cognitive function in diabetes individuals.
Using data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014, we employed generalized linear regression to assess the correlation between serum Klotho levels and cognitive function in diabetes individuals. Furthermore, a restricted cubic spline (RCS) analysis was conducted to explore the relationship, with stratified analyses by sex.
Our study included a total of 514 individuals. Serum Klotho levels were positively correlated with DSST cognitive test scores (β = 0.31, P < 0.05, P-non-linear = 0.041) and overall cognitive scores (β = 0.83, P < 0.01, P-non-linear = 0.8001) in diabetes individuals. Subsequent sex-stratified analysis revealed significant correlations, particularly in females, where an inverted U-shaped curve was observed between Klotho and DSST cognitive test scores, with a turning point at Ln(Klotho) of 6.766 pg/mL.
Elevated serum Klotho levels in diabetes individuals were associated with higher cognitive function, with this association being particularly significant in females. This study provided new evidence regarding sex differences in the association between Klotho levels and cognitive function in diabetes individuals.
Klotho、血糖水平与认知功能之间的关系已得到充分证实。然而，关于糖尿病患者中Klotho与认知功能之间关联的数据有限。
探讨糖尿病患者血清Klotho水平与认知功能之间的潜在联系。
利用2011年至2014年美国国家健康与营养检查调查（NHANES）的数据，我们采用广义线性回归评估糖尿病患者血清Klotho水平与认知功能之间的相关性。此外，进行了受限立方样条（RCS）分析以探索这种关系，并按性别进行分层分析。
我们的研究共纳入514名个体。糖尿病患者的血清Klotho水平与数字符号替换测验（DSST）认知测试得分（β = 0.31，P < 0.05，P - 非线性 = 0.041）和总体认知得分（β = 0.83，P < 0.01，P - 非线性 = 0.8001）呈正相关。随后的性别分层分析显示出显著相关性，尤其是在女性中，其中在Klotho与DSST认知测试得分之间观察到倒U形曲线，转折点处的Ln（Klotho）为6.766 pg/mL。
糖尿病患者血清Klotho水平升高与较高的认知功能相关，这种关联在女性中尤为显著。本研究提供了关于糖尿病患者中Klotho水平与认知功能之间关联的性别差异的新证据。
