Gülyüz Abdulgani
Department of Pediatrics, School of Medicine, Turgut Ozal University, 06560 Malatya, Turkey.
Diagnostics (Basel). 2025 May 27;15(11):1345. doi: 10.3390/diagnostics15111345.
The aim of this study was to investigate the relationship between primary monosymptomatic enuresis nocturna (PMNE) and vitamin D deficiency in children. This retrospective case-control study included 307 PMNE patients aged 5-18 years and 254 age- and sex-matched healthy control subjects. Demographic data and biochemical parameters of the participants were obtained from hospital records. Serum 25(OH)D3 levels were measured using the chemiluminescence immunoassay method. The Mann-Whitney U test, Chi-square test, Pearson correlation and multivariate logistic regression analysis were used for statistical analyses. Serum 25(OH)D3 levels were significantly lower in the PMNE group compared to the control group ( < 0.001). The rate of vitamin D deficiency was higher in the PMNE group. Vitamin D deficiency (OR: 3.164, 95% CI: 1.195-8.378, = 0.02) and family history of enuresis (OR: 2.790, 95% CI: 1.01-5.8, = 0.04) were found to be independent associated factors for PMNE. A significant negative correlation was found between serum vitamin D level and weekly bedwetting frequency (r = -0.377, < 0.001). Serum 25(OH)D3 levels were significantly lower in the PMNE group ( < 0.001, Cohen's d = 0.89). It is recommended that vitamin D levels should be routinely evaluated in children with PMNE and the potential benefits of vitamin D supplementation should be investigated in prospective studies.
本研究旨在探讨儿童原发性夜间单症状性遗尿症（PMNE）与维生素D缺乏之间的关系。这项回顾性病例对照研究纳入了307例年龄在5 - 18岁的PMNE患者以及254例年龄和性别匹配的健康对照者。参与者的人口统计学数据和生化参数从医院记录中获取。采用化学发光免疫分析法测定血清25(OH)D3水平。使用曼-惠特尼U检验、卡方检验、皮尔逊相关性分析和多因素逻辑回归分析进行统计分析。与对照组相比，PMNE组的血清25(OH)D3水平显著降低（< 0.001）。PMNE组维生素D缺乏率更高。发现维生素D缺乏（比值比：3.164，95%置信区间：1.195 - 8.378，P = 0.02）和遗尿家族史（比值比：2.790，95%置信区间：1.01 - 5.8，P = 0.04）是PMNE的独立相关因素。血清维生素D水平与每周尿床频率之间存在显著负相关（r = -0.377，P < 0.001）。PMNE组的血清25(OH)D3水平显著降低（< 0.001，科恩d值 = 0.89）。建议对PMNE患儿常规评估维生素D水平，并在前瞻性研究中探讨补充维生素D的潜在益处。
