Poddighe Dimitri, Zhubanova Gulsamal, Galiyeva Dinara, Mussina Kamilla, Forss Anders
College of Health Sciences, VinUniversity, Gia Lam District, Hanoi 10000, Vietnam.
School of Medicine, Nazarbayev University, 5/1 Kerey and Zhanibek Khans Street, Astana 010000, Kazakhstan.
J Clin Med. 2025 May 27;14(11):3740. doi: 10.3390/jcm14113740.
: Current evidence suggests that joint complaints can represent an extra-intestinal manifestation in patients with Celiac Disease (CD) without any rheumatic comorbidity. However, the prevalence of joint complaints in the context of both CD and rheumatic disease is not known. The aim of this study was to estimate the prevalence of joint complaints in patients with CD. : We searched Medline, Embase, Cochrane, and Web of Science databases for studies reporting joint complaints in patients with CD between 1 January 1990 and 26 November 2024. Search results were screened by two independent reviewers. The pooled prevalence of joint complaints was estimated in meta-analysis using a random effects model. We conducted stratified analyses by region, age (adults vs. children), and study sample size. The Joanna Briggs Institute Critical Appraisal Tool was used to evaluate the quality of included studies, and publication bias was assessed using a funnel plot and Egger's test. The study protocol was pre-registered in the PROSPERO database and the results were reported according to the PRISMA guidelines. : A total of 7414 publications were rendered in the search. Of these, 226 were reviewed in full text and 27 were included in the meta-analysis. Among 6901 patients with CD without any concomitant rheumatic diagnosis, 530 had joint complaints, yielding a weighted pooled prevalence of 10.7% (95%CI: 6.9-15.1). In meta-regression analysis, no association between the prevalence of joint complaints and patients' clinical characteristics or demographics was found. : This meta-analysis indicates that joint complaints in patients with CD without any specific rheumatic comorbidity are not uncommon. Increased awareness of joint complaints in CD is important to improve the diagnosis and clinical care of these patients.
目前的证据表明，关节症状可能是乳糜泻（CD）患者的一种肠外表现，且无任何风湿性合并症。然而，CD合并风湿性疾病情况下关节症状的患病率尚不清楚。本研究的目的是估计CD患者关节症状的患病率。
我们检索了Medline、Embase、Cochrane和Web of Science数据库，以查找1990年1月1日至2024年11月26日期间报告CD患者关节症状的研究。检索结果由两名独立评审员进行筛选。在荟萃分析中使用随机效应模型估计关节症状的合并患病率。我们按地区、年龄（成人与儿童）和研究样本量进行了分层分析。使用乔安娜·布里格斯研究所批判性评估工具评估纳入研究的质量，并使用漏斗图和埃格检验评估发表偏倚。研究方案已在PROSPERO数据库中预先注册，结果根据PRISMA指南报告。
检索共得到7414篇文献。其中，226篇进行了全文审查，27篇纳入荟萃分析。在6901例无任何合并风湿性诊断的CD患者中，530例有关节症状，加权合并患病率为10.7%（95%CI：6.9-15.1）。在meta回归分析中，未发现关节症状患病率与患者临床特征或人口统计学之间存在关联。
这项荟萃分析表明，无任何特定风湿性合并症的CD患者出现关节症状并不罕见。提高对CD患者关节症状的认识对于改善这些患者的诊断和临床护理很重要。
