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用于体液监测的纳米传感器和微传感器:各种分析物检测及构建解决方案。

Nanosensors and Microsensors for Body Fluid Monitoring: Various Analyte Detection and Construction Solutions.

作者信息

Lenar Nikola, Paczosa-Bator Beata

机构信息

Faculty of Materials Science and Ceramics, AGH University of Krakow, Mickiewicza 30, PL-30059 Krakow, Poland.

出版信息

Int J Mol Sci. 2025 May 22;26(11):5001. doi: 10.3390/ijms26115001.

Abstract

This review provides a comprehensive overview of the recent advancements in nanosensors and microsensors for body fluid monitoring. The principles behind sensor technologies, their applications in healthcare, and the types of body fluids that they analyze are described in the scope of this paper. Additionally, this review discusses emerging trends, challenges, and future perspectives in this field. The first two sections explore various body fluids and their diagnostic significance and discuss the fundamentals and classification of nanosensors and microsensors. The main aim of this paper is to highlight recent advancements in nanosensors for body fluid monitoring and to examine the role of microsensors in healthcare diagnostics. Innovative solutions such as microfluidic-based sensors, lab-on-a-chip systems, MEMS-based sensors, and wearable and implantable sensors are discussed in this section. Various construction solutions for microsensors and nanosensors have also been compiled and compared based on their target analytes, which are widely present in body fluids. The following sections review technologies and trends, including AI integration and flexible sensors, and discuss challenges and future perspectives in the development and application of sensors. The conclusion includes a summary of key findings and the future outlook for nanosensors and microsensors in personalized medicine.

摘要

本综述全面概述了用于体液监测的纳米传感器和微传感器的最新进展。本文范围内描述了传感器技术背后的原理、它们在医疗保健中的应用以及它们所分析的体液类型。此外,本综述还讨论了该领域的新兴趋势、挑战和未来前景。前两节探讨了各种体液及其诊断意义,并讨论了纳米传感器和微传感器的基本原理和分类。本文的主要目的是突出用于体液监测的纳米传感器的最新进展,并研究微传感器在医疗诊断中的作用。本节讨论了基于微流体的传感器、芯片实验室系统、基于MEMS的传感器以及可穿戴和可植入传感器等创新解决方案。还根据微传感器和纳米传感器的目标分析物(广泛存在于体液中)对各种构建解决方案进行了汇编和比较。以下各节回顾了技术和趋势,包括人工智能集成和柔性传感器,并讨论了传感器开发和应用中的挑战及未来前景。结论部分总结了关键发现以及纳米传感器和微传感器在个性化医疗中的未来展望。

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