Jahangiri Leila
School of Science and Technology, Nottingham Trent University, Clifton Site, Nottingham NG11 8NS, UK.
Division of Cellular and Molecular Pathology, Department of Pathology, Addenbrookes Hospital, University of Cambridge, Cambridge CB0 2QQ, UK.
Int J Mol Sci. 2025 May 28;26(11):5183. doi: 10.3390/ijms26115183.
Breast cancer is a major health concern for women worldwide, and therefore, understanding various changes acquired by breast cancer cells is relevant to a better comprehension of the disease. One such change includes alterations to the mechanical properties of breast cancer cells. For example, cells with high malignant potential show lower adhesion forces and higher cell deformability. Mechanical forces, including tensile and compressive forces of the cytoskeleton and the extracellular matrix such as integrin, collagen, and the basement membrane, can affect BC cells. These forces alter the properties of cancer cells, drive them towards invasiveness due to different motility and proliferative profiles, and change their microenvironment. This study will focus on the mechanical characteristics of breast cancer cells and the extracellular matrix. Furthermore, changes induced in breast cancer cells following exposure to mechanical forces will be reviewed. Genes that link phenotype to mechanical forces and the implications of these forces for diagnostics and treatment will be discussed.
乳腺癌是全球女性主要的健康关注点，因此，了解乳腺癌细胞获得的各种变化对于更好地理解该疾病至关重要。其中一种变化包括乳腺癌细胞力学特性的改变。例如，具有高恶性潜能的细胞表现出较低的黏附力和较高的细胞变形性。机械力，包括细胞骨架以及细胞外基质（如整合素、胶原蛋白和基底膜）的拉伸和压缩力，会影响乳腺癌细胞。这些力改变癌细胞的特性，由于不同的运动性和增殖特征促使它们具有侵袭性，并改变其微环境。本研究将聚焦于乳腺癌细胞和细胞外基质的力学特性。此外，还将综述暴露于机械力后乳腺癌细胞所诱导的变化。将讨论将表型与机械力联系起来的基因以及这些力对诊断和治疗的影响。
